| pubmed-article:15337769 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15337769 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:15337769 | lifeskim:mentions | umls-concept:C0143630 | lld:lifeskim |
| pubmed-article:15337769 | lifeskim:mentions | umls-concept:C0345967 | lld:lifeskim |
| pubmed-article:15337769 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:15337769 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:15337769 | lifeskim:mentions | umls-concept:C0324024 | lld:lifeskim |
| pubmed-article:15337769 | pubmed:issue | 45 | lld:pubmed |
| pubmed-article:15337769 | pubmed:dateCreated | 2004-11-1 | lld:pubmed |
| pubmed-article:15337769 | pubmed:abstractText | Malignant mesothelioma (MM) is strongly resistant to conventional chemotherapy by unclear mechanisms. We and others have previously reported that cytokine- and growth factor-mediated signal transduction is involved in the growth and progression of MM. Here, we identified a pathway that involves stem cell factor (SCF)/c-Kit/Slug in mediating multidrug resistance of MM cells. When we compared gene expression profiles between five MM cells and their multidrug-resistant (MM DX) sublines, we found that MM DX cells expressed both SCF and c-Kit and had higher mRNA levels of Slug. Knockdown of c-Kit or Slug expression with their respective small interfering RNA sensitized MM DX cells to the induction of apoptosis by different chemotherapeutic agents, including doxorubicin, paclitaxel, and vincristine. Transfection of c-Kit in parental MM cells in the presence of SCF up-regulated Slug and increased resistance to the chemotherapeutic agents. Moreover, MM cells expressing Slug showed a similar increased resistance to the chemotherapeutic agents. These results indicate that induction of Slug by autocrine production of SCF and c-Kit activation plays a key role in conferring a broad spectrum chemoresistance on MM cells and reveal a novel signal transduction pathway for pharmacological or genetic intervention of MM patients. | lld:pubmed |
| pubmed-article:15337769 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:15337769 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15337769 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15337769 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:15337769 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:15337769 | pubmed:author | pubmed-author:ProcopioAnton... | lld:pubmed |
| pubmed-article:15337769 | pubmed:author | pubmed-author:CatalanoAlfon... | lld:pubmed |
| pubmed-article:15337769 | pubmed:author | pubmed-author:RippoMaria... | lld:pubmed |
| pubmed-article:15337769 | pubmed:author | pubmed-author:CaprariPaolaP | lld:pubmed |
| pubmed-article:15337769 | pubmed:author | pubmed-author:RodilossiSabr... | lld:pubmed |
| pubmed-article:15337769 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15337769 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:15337769 | pubmed:volume | 279 | lld:pubmed |
| pubmed-article:15337769 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15337769 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15337769 | pubmed:pagination | 46706-14 | lld:pubmed |
| pubmed-article:15337769 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:15337769 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15337769 | pubmed:articleTitle | Induction of stem cell factor/c-Kit/slug signal transduction in multidrug-resistant malignant mesothelioma cells. | lld:pubmed |
| pubmed-article:15337769 | pubmed:affiliation | Department of Molecular Pathology and Innovative Therapies, Polytechnic University of Marche, Ancona 60131, Italy. catgfp@yahoo.it | lld:pubmed |
| pubmed-article:15337769 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15337769 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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