| pubmed-article:1533244 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1533244 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:1533244 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:1533244 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:1533244 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:1533244 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:1533244 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:1533244 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:1533244 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:1533244 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:1533244 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:1533244 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:1533244 | pubmed:dateCreated | 1992-5-26 | lld:pubmed |
| pubmed-article:1533244 | pubmed:abstractText | Recognition of conventional foreign antigen by T cells is determined by the expression of multiple variable regions of both alpha and beta chains of the T cell receptor (TCR) alpha/beta heterodimer. In contrast, there exists a class of antigens that appears to interact with the TCR alpha/beta heterodimer through the variable region on the beta chain (V beta), independent of other TCR components, a property that has led to their designation as superantigens. The goal of the present study was to analyze V alpha use in V beta 6+ T cells responsive to the superantigen, Mlaa. Results indicate that while deletion of T cells expressing V beta 6 in Mlsa-expressing mice is essentially complete and therefore appears to occur regardless of V alpha usage, in vitro Mlsa stimulation of T cells from Mlsa-negative mice results in significant skewing of V alpha use among responding V beta 6+ T cells. This indicates that V alpha expression influences recognition of the superantigen, Mlsa by mature peripheral T cells. | lld:pubmed |
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| pubmed-article:1533244 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1533244 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1533244 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1533244 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1533244 | pubmed:month | May | lld:pubmed |
| pubmed-article:1533244 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:1533244 | pubmed:author | pubmed-author:HodesR JRJ | lld:pubmed |
| pubmed-article:1533244 | pubmed:author | pubmed-author:TomonariKK | lld:pubmed |
| pubmed-article:1533244 | pubmed:author | pubmed-author:KanagawaOO | lld:pubmed |
| pubmed-article:1533244 | pubmed:author | pubmed-author:VacchioM SMS | lld:pubmed |
| pubmed-article:1533244 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1533244 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:1533244 | pubmed:volume | 175 | lld:pubmed |
| pubmed-article:1533244 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1533244 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1533244 | pubmed:pagination | 1405-8 | lld:pubmed |
| pubmed-article:1533244 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
| pubmed-article:1533244 | pubmed:meshHeading | pubmed-meshheading:1533244-... | lld:pubmed |
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| pubmed-article:1533244 | pubmed:meshHeading | pubmed-meshheading:1533244-... | lld:pubmed |
| pubmed-article:1533244 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1533244 | pubmed:articleTitle | Influence of T cell receptor V alpha expression on Mlsa superantigen-specific T cell responses. | lld:pubmed |
| pubmed-article:1533244 | pubmed:affiliation | Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892. | lld:pubmed |
| pubmed-article:1533244 | pubmed:publicationType | Journal Article | lld:pubmed |
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