Linked Life Data

15331152

Source:http://linkedlifedata.com/resource/pubmed/id/15331152

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SubjectPredicateObjectContext
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pubmed-article:15331152pubmed:dateCreated2004-8-27lld:pubmed
pubmed-article:15331152pubmed:abstractTextThe pharmacological property that most distinguishes rat P2X4 receptors from other P2X receptors is their insensitivity to the purinoceptor antagonists, suramin and pyridoxal-phosphate-6-azophenyl-2',4'-disulphonic acid (PPADS). The molecular basis of this insensitivity is not known. Here, we investigated the possibility that histidine residues in the extracellular loop of P2X4 receptors may be involved in the antagonist sensitivity of these receptors. We found that histidine mutation H241A in the rat P2X4 receptor produced receptors that are sensitive to suramin and PPADS. In contrast, mutation H140A or H286A did not significantly alter antagonist sensitivity. In addition, mutation H241A in the human P2X4 receptor significantly increased antagonist sensitivity. The results suggest that histidine 241of P2X4 receptors is involved in regulating the antagonist sensitivity of these receptors.lld:pubmed
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pubmed-article:15331152pubmed:authorpubmed-author:LiChaoyingClld:pubmed
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pubmed-article:15331152pubmed:pagination197-200lld:pubmed
pubmed-article:15331152pubmed:dateRevised2010-11-18lld:pubmed
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pubmed-article:15331152pubmed:year2004lld:pubmed
pubmed-article:15331152pubmed:articleTitleRole of extracellular histidines in antagonist sensitivity of the rat P2X4 receptor.lld:pubmed
pubmed-article:15331152pubmed:affiliationLaboratory of Molecular and Cellular Neurobiology, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892-8115, USA.lld:pubmed
pubmed-article:15331152pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15331152pubmed:publicationTypeComparative Studylld:pubmed
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