| pubmed-article:15331126 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15331126 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:15331126 | lifeskim:mentions | umls-concept:C0025202 | lld:lifeskim |
| pubmed-article:15331126 | lifeskim:mentions | umls-concept:C0002199 | lld:lifeskim |
| pubmed-article:15331126 | lifeskim:mentions | umls-concept:C0086132 | lld:lifeskim |
| pubmed-article:15331126 | lifeskim:mentions | umls-concept:C1707520 | lld:lifeskim |
| pubmed-article:15331126 | lifeskim:mentions | umls-concept:C1522673 | lld:lifeskim |
| pubmed-article:15331126 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:15331126 | pubmed:dateCreated | 2004-8-27 | lld:pubmed |
| pubmed-article:15331126 | pubmed:abstractText | Interferon-alpha (IFN-alpha) treatment is frequently complicated by symptoms of depression. The mechanism by which peripherally administered IFN-alpha enters and modulates the central nervous system remains unclear. The cell adhesion molecule ICAM-1 is involved in the regulation of blood-brain barrier (BBB) permeability. ICAM-1 expression was shown to increase during IFN-alpha treatment and recently the expression of ICAM-1 on vascular endothelial cells in the brain was found to be correlated with the development of depression. We therefore hypothesized that soluble ICAM-1 may be involved in the development of IFN-alpha associated depression. In a prospective study, serum levels of soluble ICAM-1 (double sandwich ELISA test) and symptoms of depression (SDS) were measured in 48 patients with malignant melanoma before and during adjuvant IFN-alpha treatment. Both, depression scores and the serum levels of sICAM-1 significantly increased after three months of IFN-alpha treatment compared to baseline levels (p < .001). Patients who developed depression (SDS-index scores > or = 50) after three months of treatment had higher sICAM-1 levels compared to non-depressed patients. Furthermore, sICAM-1 levels were positively correlated with SDS values (r = .367, p = .018). Our data provides evidence for an association between the induction of sICAM-1 and the development of symptoms of depression during IFN-alpha treatment, possibly by enhancing BBB-permeability. | lld:pubmed |
| pubmed-article:15331126 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15331126 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15331126 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15331126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15331126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15331126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15331126 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15331126 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15331126 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:15331126 | pubmed:issn | 0889-1591 | lld:pubmed |
| pubmed-article:15331126 | pubmed:author | pubmed-author:AckenheilManf... | lld:pubmed |
| pubmed-article:15331126 | pubmed:author | pubmed-author:HornMartinM | lld:pubmed |
| pubmed-article:15331126 | pubmed:author | pubmed-author:VolkenandtMat... | lld:pubmed |
| pubmed-article:15331126 | pubmed:author | pubmed-author:SchwarzMarkus... | lld:pubmed |
| pubmed-article:15331126 | pubmed:author | pubmed-author:Schmid-Wendtn... | lld:pubmed |
| pubmed-article:15331126 | pubmed:author | pubmed-author:SchaeferMarti... | lld:pubmed |
| pubmed-article:15331126 | pubmed:author | pubmed-author:SchmidtFolkha... | lld:pubmed |
| pubmed-article:15331126 | pubmed:author | pubmed-author:MuellerNorber... | lld:pubmed |
| pubmed-article:15331126 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15331126 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:15331126 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15331126 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15331126 | pubmed:pagination | 555-62 | lld:pubmed |
| pubmed-article:15331126 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:15331126 | pubmed:meshHeading | pubmed-meshheading:15331126... | lld:pubmed |
| pubmed-article:15331126 | pubmed:meshHeading | pubmed-meshheading:15331126... | lld:pubmed |
| pubmed-article:15331126 | pubmed:meshHeading | pubmed-meshheading:15331126... | lld:pubmed |
| pubmed-article:15331126 | pubmed:meshHeading | pubmed-meshheading:15331126... | lld:pubmed |
| pubmed-article:15331126 | pubmed:meshHeading | pubmed-meshheading:15331126... | lld:pubmed |
| pubmed-article:15331126 | pubmed:meshHeading | pubmed-meshheading:15331126... | lld:pubmed |
| pubmed-article:15331126 | pubmed:meshHeading | pubmed-meshheading:15331126... | lld:pubmed |
| pubmed-article:15331126 | pubmed:meshHeading | pubmed-meshheading:15331126... | lld:pubmed |
| pubmed-article:15331126 | pubmed:meshHeading | pubmed-meshheading:15331126... | lld:pubmed |
| pubmed-article:15331126 | pubmed:meshHeading | pubmed-meshheading:15331126... | lld:pubmed |
| pubmed-article:15331126 | pubmed:meshHeading | pubmed-meshheading:15331126... | lld:pubmed |
| pubmed-article:15331126 | pubmed:meshHeading | pubmed-meshheading:15331126... | lld:pubmed |
| pubmed-article:15331126 | pubmed:meshHeading | pubmed-meshheading:15331126... | lld:pubmed |
| pubmed-article:15331126 | pubmed:meshHeading | pubmed-meshheading:15331126... | lld:pubmed |
| pubmed-article:15331126 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15331126 | pubmed:articleTitle | Correlation between sICAM-1 and depressive symptoms during adjuvant treatment of melanoma with interferon-alpha. | lld:pubmed |
| pubmed-article:15331126 | pubmed:affiliation | Department of Psychiatry, Charité-University Medicine Berlin, Campus Charité Mitte, Schumannstr. 20/21, D-10117 Berlin, Germany. martin.schaefer@charite.de | lld:pubmed |
| pubmed-article:15331126 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15331126 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:15331126 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15331126 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
