pubmed-article:15320916 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:15320916 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
pubmed-article:15320916 | lifeskim:mentions | umls-concept:C0003873 | lld:lifeskim |
pubmed-article:15320916 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
pubmed-article:15320916 | lifeskim:mentions | umls-concept:C0383327 | lld:lifeskim |
pubmed-article:15320916 | lifeskim:mentions | umls-concept:C0229671 | lld:lifeskim |
pubmed-article:15320916 | lifeskim:mentions | umls-concept:C0020855 | lld:lifeskim |
pubmed-article:15320916 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
pubmed-article:15320916 | lifeskim:mentions | umls-concept:C0151449 | lld:lifeskim |
pubmed-article:15320916 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
pubmed-article:15320916 | pubmed:issue | 3 | lld:pubmed |
pubmed-article:15320916 | pubmed:dateCreated | 2004-8-23 | lld:pubmed |
pubmed-article:15320916 | pubmed:abstractText | Primary Sjögren's syndrome (SS) is characterized by inflammation in salivary and lachrymal glands, with a local predominance of Th1-like cytokines, as well as the pleiotropic cytokine interleukin (IL) 18. High serum levels of polyclonal IgG are common, with a subclass imbalance in which IgG1 is increased and IgG2 is normal or low. IL-18 is also of pathogenetic importance in rheumatoid arthritis. In the present study we looked for any relationship between serum IL-18 as well as transforming growth factor (TGF) beta1 versus IgA, IgM, and IgG subclass levels in SS (n = 16), rheumatoid arthritis (RA) (n = 15), and healthy controls (n = 15). SS was defined by the revised American-European classification criteria. IL-18 and TGF-beta1 were analyzed with enzyme immunoassays (EIA), and IgG1, IgG2 and IgG3 by single radial immunodiffusion. In the composite group of RA, SS and normal controls, IgG1 and IL-18 were related (R = 0.52, P = 0.0005). No relation was found neither between IL-18 versus IgG2, IgG3 or IgA, nor between serum TGF-beta1 versus any of the immunoglobulins. Since serum levels of IL-18 are related to serum IgG1, IL-18 may be of importance for IgG1 switch and/or release. | lld:pubmed |
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pubmed-article:15320916 | pubmed:language | eng | lld:pubmed |
pubmed-article:15320916 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15320916 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:15320916 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15320916 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:15320916 | pubmed:month | Sep | lld:pubmed |
pubmed-article:15320916 | pubmed:issn | 0009-9104 | lld:pubmed |
pubmed-article:15320916 | pubmed:author | pubmed-author:AnderssonCC | lld:pubmed |
pubmed-article:15320916 | pubmed:author | pubmed-author:ErikssonPP | lld:pubmed |
pubmed-article:15320916 | pubmed:author | pubmed-author:SkoghTT | lld:pubmed |
pubmed-article:15320916 | pubmed:author | pubmed-author:ErnerudhJJ | lld:pubmed |
pubmed-article:15320916 | pubmed:author | pubmed-author:EkerfeltCC | lld:pubmed |
pubmed-article:15320916 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:15320916 | pubmed:volume | 137 | lld:pubmed |
pubmed-article:15320916 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:15320916 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:15320916 | pubmed:pagination | 617-20 | lld:pubmed |
pubmed-article:15320916 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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pubmed-article:15320916 | pubmed:meshHeading | pubmed-meshheading:15320916... | lld:pubmed |
pubmed-article:15320916 | pubmed:year | 2004 | lld:pubmed |
pubmed-article:15320916 | pubmed:articleTitle | Relationship between serum levels of IL-18 and IgG1 in patients with primary Sjögren's syndrome, rheumatoid arthritis and healthy controls. | lld:pubmed |
pubmed-article:15320916 | pubmed:affiliation | Division of Rheumatology, Linköping University Hospital, Linköping, Sweden. per.eriksson@lio.se | lld:pubmed |
pubmed-article:15320916 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:15320916 | pubmed:publicationType | Comparative Study | lld:pubmed |
pubmed-article:15320916 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15320916 | lld:pubmed |