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pubmed-article:15318937pubmed:abstractTextImproving technologies for the detection and purification of bone marrow (BM) micrometastatic cells in breast cancer patients should lead to earlier prognosis of the risk of relapse and should make it possible to design more appropriate therapies. The technique used has to overcome the challenges resulting from the small number of target cells (one per million hematopoietic cells) and the heterogeneous expression of micrometastatic cell markers. In the present study, we have assessed the clinical relevance of current methods aimed at detecting rare disseminated carcinoma cells.lld:pubmed
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pubmed-article:15318937pubmed:articleTitleEnrichment methods to detect bone marrow micrometastases in breast carcinoma patients: clinical relevance.lld:pubmed
pubmed-article:15318937pubmed:affiliationUMR144 CNRS, Research Division, Institut Curie, Paris, France. vchoesmel@yahoo.frlld:pubmed
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