| pubmed-article:15317867 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15317867 | lifeskim:mentions | umls-concept:C0178453 | lld:lifeskim |
| pubmed-article:15317867 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:15317867 | lifeskim:mentions | umls-concept:C0450429 | lld:lifeskim |
| pubmed-article:15317867 | lifeskim:mentions | umls-concept:C0008633 | lld:lifeskim |
| pubmed-article:15317867 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:15317867 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:15317867 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:15317867 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:15317867 | pubmed:issue | 15 | lld:pubmed |
| pubmed-article:15317867 | pubmed:dateCreated | 2004-8-19 | lld:pubmed |
| pubmed-article:15317867 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15317867 | pubmed:abstractText | The mating-type region of the fission yeast Schizosaccharomyces pombe comprises three loci: mat1, mat2-P and mat3-M. mat1 is expressed and determines the mating type of the cell. mat2-P and mat3-M are two storage cassettes located in a 17 kb heterochromatic region with features identical to those of mammalian heterochromatin. Mutations in the swi6+, clr1+, clr2+, clr3+, clr4+ and clr6+ genes were obtained in screens for factors necessary for silencing the mat2-P-mat3-M region. swi6+ encodes a chromodomain protein, clr3+ and clr6+ histone deacetylases, and clr4+ a histone methyltransferase. Here, we describe the cloning and characterization of clr2+. The clr2+ gene encodes a 62 kDa protein with no obvious sequence homologs. Deletion of clr2+ not only affects transcriptional repression in the mating-type region, but also centromeric silencing and silencing of a PolII-transcribed gene inserted in the rDNA repeats. Using chromatin immunoprecipitation, we show that Clr2 is necessary for histone hypoacetylation in the mating-type region, suggesting that Clr2 acts upstream of histone deacetylases to promote transcriptional silencing. | lld:pubmed |
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| pubmed-article:15317867 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15317867 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15317867 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15317867 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15317867 | pubmed:issn | 1362-4962 | lld:pubmed |
| pubmed-article:15317867 | pubmed:author | pubmed-author:BjerlingPerni... | lld:pubmed |
| pubmed-article:15317867 | pubmed:author | pubmed-author:ThonGeneviève... | lld:pubmed |
| pubmed-article:15317867 | pubmed:author | pubmed-author:EkwallKarlK | lld:pubmed |
| pubmed-article:15317867 | pubmed:author | pubmed-author:EgelRichardR | lld:pubmed |
| pubmed-article:15317867 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:15317867 | pubmed:volume | 32 | lld:pubmed |
| pubmed-article:15317867 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15317867 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15317867 | pubmed:pagination | 4421-8 | lld:pubmed |
| pubmed-article:15317867 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:15317867 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15317867 | pubmed:articleTitle | A novel type of silencing factor, Clr2, is necessary for transcriptional silencing at various chromosomal locations in the fission yeast Schizosaccharomyces pombe. | lld:pubmed |
| pubmed-article:15317867 | pubmed:affiliation | Department of Biosciences, Karolinska Institutet, Sodertorn University College, 141 89 Huddinge, Sweden. Pernilla.Bjerling@imbim.uu.se | lld:pubmed |
| pubmed-article:15317867 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15317867 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:2542596 | entrezgene:pubmed | pubmed-article:15317867 | lld:entrezgene |
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