| pubmed-article:15312910 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15312910 | lifeskim:mentions | umls-concept:C0086287 | lld:lifeskim |
| pubmed-article:15312910 | lifeskim:mentions | umls-concept:C0014912 | lld:lifeskim |
| pubmed-article:15312910 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:15312910 | lifeskim:mentions | umls-concept:C0001721 | lld:lifeskim |
| pubmed-article:15312910 | lifeskim:mentions | umls-concept:C0086582 | lld:lifeskim |
| pubmed-article:15312910 | lifeskim:mentions | umls-concept:C1418835 | lld:lifeskim |
| pubmed-article:15312910 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:15312910 | pubmed:dateCreated | 2004-8-17 | lld:pubmed |
| pubmed-article:15312910 | pubmed:abstractText | Estrogen (E) treatment of ovariectomized animals increases dendritic spines and/or synaptic protein expression in the hippocampus of female rats [J Neurosci 12 (1992) 2549; Endocrinology 142 (2001) 1284; Endocrinol Rev 20 (1999) 279; Annu Rev Pharmacol Toxicol 41 (2001) 569], mice [Proc Natl Acad Sci USA 101 (2004) 2185], rhesus monkeys [Proc Natl Acad Sci USA 98 (2001) 8071; Endocrinology 144 (2003) 4734; J Comp Neurol 465 (2003) 540] and hippocampal cells in vitro [J Neurosci 16 (1996) 4059; Neuroscience 124 (2004) 549]. The role of E in hippocampal synaptic structural plasticity in males is less well understood. In the present study, we have used a recently developed technique to count spinophilin immunogold-reactive (Ir) puncta as well as in situ hybridization to compare E effects on spinophilin-Ir and mRNA in gonadectomized female and male rats 48 h after E treatment. Spinophilin is an established spine marker, which interacts with several proteins (including actin and protein phosphatase 1) that are highly enriched in spines [Proc Natl Acad Sci USA 94 (1997) 9956; Proc Natl Acad Sci USA 97 (2000) 9287]. We report that E exerts sex-specific effects on dendritic spinophilin-labeled spines in the CA1 region: E treatment significantly increased spinophilin-Ir puncta, indicative of spines, in females, but led to a decrease in males. Furthermore, while hippocampal spinophilin mRNA changes could have occurred earlier, spinophilin mRNA levels were unchanged after 48 h of E in both males and females. This suggests the possibility that E regulates spinophilin protein expression and or stability within dendrites via post-transcriptional mechanisms. | lld:pubmed |
| pubmed-article:15312910 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15312910 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15312910 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15312910 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15312910 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15312910 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15312910 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15312910 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15312910 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15312910 | pubmed:issn | 0306-4522 | lld:pubmed |
| pubmed-article:15312910 | pubmed:author | pubmed-author:GreengardPP | lld:pubmed |
| pubmed-article:15312910 | pubmed:author | pubmed-author:McEwenB SBS | lld:pubmed |
| pubmed-article:15312910 | pubmed:author | pubmed-author:LeeS JSJ | lld:pubmed |
| pubmed-article:15312910 | pubmed:author | pubmed-author:AllenP BPB | lld:pubmed |
| pubmed-article:15312910 | pubmed:author | pubmed-author:SvenningssonP... | lld:pubmed |
| pubmed-article:15312910 | pubmed:author | pubmed-author:RomeoR DRD | lld:pubmed |
| pubmed-article:15312910 | pubmed:author | pubmed-author:CampomanesC... | lld:pubmed |
| pubmed-article:15312910 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15312910 | pubmed:volume | 127 | lld:pubmed |
| pubmed-article:15312910 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15312910 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15312910 | pubmed:pagination | 983-8 | lld:pubmed |
| pubmed-article:15312910 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:15312910 | pubmed:meshHeading | pubmed-meshheading:15312910... | lld:pubmed |
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| pubmed-article:15312910 | pubmed:meshHeading | pubmed-meshheading:15312910... | lld:pubmed |
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| pubmed-article:15312910 | pubmed:meshHeading | pubmed-meshheading:15312910... | lld:pubmed |
| pubmed-article:15312910 | pubmed:meshHeading | pubmed-meshheading:15312910... | lld:pubmed |
| pubmed-article:15312910 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15312910 | pubmed:articleTitle | Estradiol affects spinophilin protein differently in gonadectomized males and females. | lld:pubmed |
| pubmed-article:15312910 | pubmed:affiliation | Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, Box 165, 1230 York Avenue, New York, NY 10021, USA. leesus@rockefeller.edu | lld:pubmed |
| pubmed-article:15312910 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15312910 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15312910 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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