| pubmed-article:15308487 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15308487 | lifeskim:mentions | umls-concept:C0032961 | lld:lifeskim |
| pubmed-article:15308487 | lifeskim:mentions | umls-concept:C0683572 | lld:lifeskim |
| pubmed-article:15308487 | lifeskim:mentions | umls-concept:C0007226 | lld:lifeskim |
| pubmed-article:15308487 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:15308487 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:15308487 | lifeskim:mentions | umls-concept:C0012155 | lld:lifeskim |
| pubmed-article:15308487 | lifeskim:mentions | umls-concept:C0277785 | lld:lifeskim |
| pubmed-article:15308487 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:15308487 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15308487 | pubmed:dateCreated | 2004-12-13 | lld:pubmed |
| pubmed-article:15308487 | pubmed:abstractText | Epidemiological and animal studies suggest that diet-induced epigenetic modifications in early life can contribute to development of the metabolic syndrome in adulthood. We previously reported features of the metabolic syndrome in adult offspring of rats fed a diet rich in animal fat during pregnancy and suckling. We now report a study to compare the relative effects of high-fat feeding during 1) pregnancy and 2) the suckling period in the development of these disorders. As observed previously, 6-mo-old female offspring of fat-fed dams suckled by the same fat-fed dams (OHF) demonstrated raised blood pressure, despite being fed a balanced diet from weaning. Female offspring of fat-fed dams "cross fostered" to dams consuming a control diet during suckling (OHF/C) demonstrated raised blood pressure compared with controls (OC) [systolic blood pressure (SBP; mmHg) means +/- SE: OHF/C, 132.5 +/- 3.0, n = 6 vs. OC, 119.0 +/- 3.8, n = 7, P < 0.05]. Female offspring of controls cross fostered to dams consuming the fat diet (OC/HF) were also hypertensive [SBP (mmHg) 131.0 +/- 2.5 mmHg, n = 6 vs. OC, P < 0.05]. Endothelium-dependent relaxation (EDR) of male and female OHF and OHF/C mesenteric small arteries was similar and blunted compared with OC (P < 0.001). OC/HF arteries showed profoundly impaired EDR (OC/HF vs. OHF, P < 0.001). OHF/C and OC/HF demonstrated hyperinsulinemia and increased adiposity. Features of the metabolic syndrome in adult offspring of fat-fed rats can be acquired both antenatally and during suckling. However, exposure during pregnancy confers adaptive protection against endothelial dysfunction induced by maternal fat feeding during suckling. | lld:pubmed |
| pubmed-article:15308487 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15308487 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15308487 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15308487 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15308487 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15308487 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:15308487 | pubmed:issn | 0363-6119 | lld:pubmed |
| pubmed-article:15308487 | pubmed:author | pubmed-author:JensenRR | lld:pubmed |
| pubmed-article:15308487 | pubmed:author | pubmed-author:HansonM AMA | lld:pubmed |
| pubmed-article:15308487 | pubmed:author | pubmed-author:PostonLL | lld:pubmed |
| pubmed-article:15308487 | pubmed:author | pubmed-author:TaylorP DPD | lld:pubmed |
| pubmed-article:15308487 | pubmed:author | pubmed-author:DouglasGG | lld:pubmed |
| pubmed-article:15308487 | pubmed:author | pubmed-author:DekouVV | lld:pubmed |
| pubmed-article:15308487 | pubmed:author | pubmed-author:KhanI YIY | lld:pubmed |
| pubmed-article:15308487 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15308487 | pubmed:volume | 288 | lld:pubmed |
| pubmed-article:15308487 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15308487 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15308487 | pubmed:pagination | R127-33 | lld:pubmed |
| pubmed-article:15308487 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:15308487 | pubmed:meshHeading | pubmed-meshheading:15308487... | lld:pubmed |
| pubmed-article:15308487 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15308487 | pubmed:articleTitle | A high-fat diet during rat pregnancy or suckling induces cardiovascular dysfunction in adult offspring. | lld:pubmed |
| pubmed-article:15308487 | pubmed:affiliation | Maternal and Fetal Research Unit, Division of Reproductive Health, Endocrinology and Development,King's College, London, UK. | lld:pubmed |
| pubmed-article:15308487 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15308487 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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