| pubmed-article:15305184 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15305184 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:15305184 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:15305184 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:15305184 | lifeskim:mentions | umls-concept:C1333134 | lld:lifeskim |
| pubmed-article:15305184 | lifeskim:mentions | umls-concept:C0450442 | lld:lifeskim |
| pubmed-article:15305184 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:15305184 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:15305184 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:15305184 | pubmed:dateCreated | 2004-10-11 | lld:pubmed |
| pubmed-article:15305184 | pubmed:abstractText | A new human, compact antibody was engineered by fusion of a human, antitumour ErbB2-directed scFv with a human IgG1 Fc domain. Overexpression of the ErbB2 receptor is related to tumour aggressiveness and poor prognosis. This new immunoagent meets all criteria for a potential anticancer drug: it is human, hence poorly or not immunogenic; it binds selectively and with high affinity to target cells, on which it exerts an effective and selective antiproliferative action, including both antibody-dependent and complement-dependent cytotoxicity; it effectively inhibits tumour growth in vivo. Its compact molecular size should provide for an efficient tissue penetration, yet suitable to a prolonged serum half-life. | lld:pubmed |
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| pubmed-article:15305184 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15305184 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15305184 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15305184 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15305184 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:15305184 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:15305184 | pubmed:author | pubmed-author:LaccettiPP | lld:pubmed |
| pubmed-article:15305184 | pubmed:author | pubmed-author:D'AlessioGG | lld:pubmed |
| pubmed-article:15305184 | pubmed:author | pubmed-author:De LorenziEE | lld:pubmed |
| pubmed-article:15305184 | pubmed:author | pubmed-author:CozzolinoRR | lld:pubmed |
| pubmed-article:15305184 | pubmed:author | pubmed-author:PiccoliRR | lld:pubmed |
| pubmed-article:15305184 | pubmed:author | pubmed-author:TedescoAA | lld:pubmed |
| pubmed-article:15305184 | pubmed:author | pubmed-author:TerrazzanoGG | lld:pubmed |
| pubmed-article:15305184 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15305184 | pubmed:day | 13 | lld:pubmed |
| pubmed-article:15305184 | pubmed:volume | 91 | lld:pubmed |
| pubmed-article:15305184 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15305184 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15305184 | pubmed:pagination | 1200-4 | lld:pubmed |
| pubmed-article:15305184 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:15305184 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15305184 | pubmed:articleTitle | A human, compact, fully functional anti-ErbB2 antibody as a novel antitumour agent. | lld:pubmed |
| pubmed-article:15305184 | pubmed:affiliation | Department of Biological Chemistry, University of Naples Federico II, Via Mezzocannone 16, 80134 Naples, Italy. | lld:pubmed |
| pubmed-article:15305184 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15305184 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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