| pubmed-article:15304998 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15304998 | lifeskim:mentions | umls-concept:C0025663 | lld:lifeskim |
| pubmed-article:15304998 | lifeskim:mentions | umls-concept:C0205103 | lld:lifeskim |
| pubmed-article:15304998 | lifeskim:mentions | umls-concept:C0029995 | lld:lifeskim |
| pubmed-article:15304998 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:15304998 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:15304998 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:15304998 | pubmed:dateCreated | 2004-8-12 | lld:pubmed |
| pubmed-article:15304998 | pubmed:abstractText | Mild, efficient and eco-friendly oxidation of 17alpha-methylandrostan-3beta-17beta-diol (1) has been studied with three different reagents viz. pentavalent iodine reagent 2-iodoxy benzoic acid (IBX) in DMSO at 65 degrees C, sodium hypochlorite and H2O2/Na2WO4 under phase transfer conditions to give 17beta-hydroxy-17alpha-methylandrostan-3-one (mestanolone 2), a drug intermediate as oxidized product. The H2O2/Na2WO4/PTC gave mestanolone in high yield and purity whereas sodium hypochlorite/PTC system yielded some chlorinated material along with the mestanolone. However, 1 with 2.5 equivalent of IBX gave 17beta-hydroxy-17alpha-methyl-Delta1-androsten-3-one (3) under the similar reaction conditions in good yield and single step reaction. | lld:pubmed |
| pubmed-article:15304998 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15304998 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15304998 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15304998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15304998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15304998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15304998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15304998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15304998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15304998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15304998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15304998 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15304998 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:15304998 | pubmed:issn | 0009-2363 | lld:pubmed |
| pubmed-article:15304998 | pubmed:author | pubmed-author:SinghManishM | lld:pubmed |
| pubmed-article:15304998 | pubmed:author | pubmed-author:ChandraRamesh... | lld:pubmed |
| pubmed-article:15304998 | pubmed:author | pubmed-author:TandonVibhaV | lld:pubmed |
| pubmed-article:15304998 | pubmed:author | pubmed-author:GinotraSandee... | lld:pubmed |
| pubmed-article:15304998 | pubmed:author | pubmed-author:ChhikaraBhupe... | lld:pubmed |
| pubmed-article:15304998 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15304998 | pubmed:volume | 52 | lld:pubmed |
| pubmed-article:15304998 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15304998 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15304998 | pubmed:pagination | 989-91 | lld:pubmed |
| pubmed-article:15304998 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:15304998 | pubmed:meshHeading | pubmed-meshheading:15304998... | lld:pubmed |
| pubmed-article:15304998 | pubmed:meshHeading | pubmed-meshheading:15304998... | lld:pubmed |
| pubmed-article:15304998 | pubmed:meshHeading | pubmed-meshheading:15304998... | lld:pubmed |
| pubmed-article:15304998 | pubmed:meshHeading | pubmed-meshheading:15304998... | lld:pubmed |
| pubmed-article:15304998 | pubmed:meshHeading | pubmed-meshheading:15304998... | lld:pubmed |
| pubmed-article:15304998 | pubmed:meshHeading | pubmed-meshheading:15304998... | lld:pubmed |
| pubmed-article:15304998 | pubmed:meshHeading | pubmed-meshheading:15304998... | lld:pubmed |
| pubmed-article:15304998 | pubmed:meshHeading | pubmed-meshheading:15304998... | lld:pubmed |
| pubmed-article:15304998 | pubmed:meshHeading | pubmed-meshheading:15304998... | lld:pubmed |
| pubmed-article:15304998 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15304998 | pubmed:articleTitle | Efficient oxidizing methods for the synthesis of oxandrolone intermediates. | lld:pubmed |
| pubmed-article:15304998 | pubmed:affiliation | Medicinal Chemistry Research Laboratory, Dr. B. R. Ambedkar Center for Biomedical Research, University of Delhi, Dehli, India. | lld:pubmed |
| pubmed-article:15304998 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15304998 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
