| pubmed-article:15304644 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15304644 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:15304644 | lifeskim:mentions | umls-concept:C2350466 | lld:lifeskim |
| pubmed-article:15304644 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:15304644 | lifeskim:mentions | umls-concept:C0017978 | lld:lifeskim |
| pubmed-article:15304644 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:15304644 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:15304644 | lifeskim:mentions | umls-concept:C0678894 | lld:lifeskim |
| pubmed-article:15304644 | lifeskim:mentions | umls-concept:C1710548 | lld:lifeskim |
| pubmed-article:15304644 | lifeskim:mentions | umls-concept:C1513371 | lld:lifeskim |
| pubmed-article:15304644 | pubmed:issue | 33 | lld:pubmed |
| pubmed-article:15304644 | pubmed:dateCreated | 2004-8-18 | lld:pubmed |
| pubmed-article:15304644 | pubmed:abstractText | Natural killer (NK) T cells with an invariant Valpha14 rearrangement (Valpha14i) are the largest population of lipid antigen-specific T lymphocytes identified in animals. They react to the glycolipid alpha-galactosyl ceramide (alpha-GalCer) presented by CD1d, and they may have important regulatory functions. It was previously shown that the Valpha14i T cell antigen receptor (TCR) has a high affinity for the alpha-GalCer/CD1d complex, driven by a long half-life (t(1/2)). Although this result could have reflected the unique attributes of alpha-GalCer, using several related glycolipid compounds, we show here that the threshold for full activation of Valpha14i NKT cells by these glycosphingolipids requires a relatively high-affinity TCR interaction with a long t(1/2). Furthermore, our data are consistent with the view that the mechanism of recognition of these compounds presented by CD1d to the Valpha14i NKT cell TCR is likely to fit a lock-and-key model. Overall, these findings emphasize the distinct properties of glycosphingolipid antigen recognition by Valpha14i NKT cells. | lld:pubmed |
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| pubmed-article:15304644 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:15304644 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15304644 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15304644 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:15304644 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:15304644 | pubmed:author | pubmed-author:BesraGurdyal... | lld:pubmed |
| pubmed-article:15304644 | pubmed:author | pubmed-author:KronenbergMit... | lld:pubmed |
| pubmed-article:15304644 | pubmed:author | pubmed-author:HammondKirste... | lld:pubmed |
| pubmed-article:15304644 | pubmed:author | pubmed-author:PorcelliSteve... | lld:pubmed |
| pubmed-article:15304644 | pubmed:author | pubmed-author:HowellAmy RAR | lld:pubmed |
| pubmed-article:15304644 | pubmed:author | pubmed-author:SidobreStépha... | lld:pubmed |
| pubmed-article:15304644 | pubmed:author | pubmed-author:NdonyeRachel... | lld:pubmed |
| pubmed-article:15304644 | pubmed:author | pubmed-author:MaltsevSergei... | lld:pubmed |
| pubmed-article:15304644 | pubmed:author | pubmed-author:SakaiTeruyuki... | lld:pubmed |
| pubmed-article:15304644 | pubmed:author | pubmed-author:RichardsonSte... | lld:pubmed |
| pubmed-article:15304644 | pubmed:author | pubmed-author:Bénazet-Sidob... | lld:pubmed |
| pubmed-article:15304644 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15304644 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:15304644 | pubmed:volume | 101 | lld:pubmed |
| pubmed-article:15304644 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15304644 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15304644 | pubmed:pagination | 12254-9 | lld:pubmed |
| pubmed-article:15304644 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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