| pubmed-article:15299025 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15299025 | lifeskim:mentions | umls-concept:C0162508 | lld:lifeskim |
| pubmed-article:15299025 | lifeskim:mentions | umls-concept:C0521447 | lld:lifeskim |
| pubmed-article:15299025 | lifeskim:mentions | umls-concept:C0385469 | lld:lifeskim |
| pubmed-article:15299025 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:15299025 | lifeskim:mentions | umls-concept:C1550548 | lld:lifeskim |
| pubmed-article:15299025 | lifeskim:mentions | umls-concept:C1555714 | lld:lifeskim |
| pubmed-article:15299025 | lifeskim:mentions | umls-concept:C1705654 | lld:lifeskim |
| pubmed-article:15299025 | pubmed:issue | 42 | lld:pubmed |
| pubmed-article:15299025 | pubmed:dateCreated | 2004-10-11 | lld:pubmed |
| pubmed-article:15299025 | pubmed:abstractText | Overexpression of the integrin-linked kinase (ILK) was shown to increase c-Jun-dependent transcription. We now show that this effect of ILK involves the c-Jun transcriptional coactivator, nascent polypeptide-associated complex and coactivator alpha (alpha-NAC). ILK phosphorylated alpha-NAC on residue Ser-43 upon adhesion of cells to fibronectin. Co-expression of constitutively active ILK with alpha-NAC led to the nuclear accumulation of the coactivator. Conversely, alpha-NAC remained in the cytoplasm of cells transfected with a dominant-negative ILK mutant, and a mutated alpha-NAC at phosphoacceptor position Ser-43 (S43A) also localized outside of the nucleus. The S43A alpha-NAC mutant could not potentiate the effect of ILK on c-Jun-dependent transcription. We conclude that ILK-dependent phosphorylation of alpha-NAC induced the nuclear accumulation of the coactivator and that phosphorylation of alpha-NAC by ILK is required for the potentiation of c-Jun-mediated responses by the kinase. The results represent one of the rare examples of a transcriptional coactivator shuttling between the cytosol and the nucleus. | lld:pubmed |
| pubmed-article:15299025 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15299025 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15299025 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15299025 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15299025 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15299025 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15299025 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15299025 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15299025 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15299025 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15299025 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15299025 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15299025 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15299025 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:15299025 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:15299025 | pubmed:author | pubmed-author:DedharShoukat... | lld:pubmed |
| pubmed-article:15299025 | pubmed:author | pubmed-author:GauthierClaud... | lld:pubmed |
| pubmed-article:15299025 | pubmed:author | pubmed-author:St-ArnaudRené... | lld:pubmed |
| pubmed-article:15299025 | pubmed:author | pubmed-author:HanniganGrego... | lld:pubmed |
| pubmed-article:15299025 | pubmed:author | pubmed-author:QuéloIsabelle... | lld:pubmed |
| pubmed-article:15299025 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15299025 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:15299025 | pubmed:volume | 279 | lld:pubmed |
| pubmed-article:15299025 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15299025 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15299025 | pubmed:pagination | 43893-9 | lld:pubmed |
| pubmed-article:15299025 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:15299025 | pubmed:meshHeading | pubmed-meshheading:15299025... | lld:pubmed |
| pubmed-article:15299025 | pubmed:meshHeading | pubmed-meshheading:15299025... | lld:pubmed |
| pubmed-article:15299025 | pubmed:meshHeading | pubmed-meshheading:15299025... | lld:pubmed |
| pubmed-article:15299025 | pubmed:meshHeading | pubmed-meshheading:15299025... | lld:pubmed |
| pubmed-article:15299025 | pubmed:meshHeading | pubmed-meshheading:15299025... | lld:pubmed |
| pubmed-article:15299025 | pubmed:meshHeading | pubmed-meshheading:15299025... | lld:pubmed |
| pubmed-article:15299025 | pubmed:meshHeading | pubmed-meshheading:15299025... | lld:pubmed |
| pubmed-article:15299025 | pubmed:meshHeading | pubmed-meshheading:15299025... | lld:pubmed |
| pubmed-article:15299025 | pubmed:meshHeading | pubmed-meshheading:15299025... | lld:pubmed |
| pubmed-article:15299025 | pubmed:meshHeading | pubmed-meshheading:15299025... | lld:pubmed |
| pubmed-article:15299025 | pubmed:meshHeading | pubmed-meshheading:15299025... | lld:pubmed |
| pubmed-article:15299025 | pubmed:meshHeading | pubmed-meshheading:15299025... | lld:pubmed |
| pubmed-article:15299025 | pubmed:meshHeading | pubmed-meshheading:15299025... | lld:pubmed |
| pubmed-article:15299025 | pubmed:meshHeading | pubmed-meshheading:15299025... | lld:pubmed |
| pubmed-article:15299025 | pubmed:meshHeading | pubmed-meshheading:15299025... | lld:pubmed |
| pubmed-article:15299025 | pubmed:meshHeading | pubmed-meshheading:15299025... | lld:pubmed |
| pubmed-article:15299025 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15299025 | pubmed:articleTitle | Integrin-linked kinase regulates the nuclear entry of the c-Jun coactivator alpha-NAC and its coactivation potency. | lld:pubmed |
| pubmed-article:15299025 | pubmed:affiliation | Genetics Unit, Shriners Hospital for Children Montréal, Québec H3G 1A6, Canada. | lld:pubmed |
| pubmed-article:15299025 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15299025 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:17938 | entrezgene:pubmed | pubmed-article:15299025 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15299025 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15299025 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15299025 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15299025 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15299025 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15299025 | lld:pubmed |
