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pubmed-article:15296099pubmed:abstractTextIn the present study, a first-generation adenovirus (Ad) vector was modified with the RGD peptide inserted into the fiber. The insertion of an integrin-targeting sequence into the Ad vector notably enhanced the luciferase expression in the Coxsackie virus and Adenovirus Receptor-deficient A2058 and B16BL6 melanoma cells. The results of an in vivo study with tumor-bearing mice also showed that Ad-RGD-Luc had enhanced gene expression in many organs and in the B16BL6 tumor compared to that induced by a conventional Ad vector after intravenous injection.lld:pubmed
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pubmed-article:15296099pubmed:articleTitleHigh gene expression of the mutant adenovirus vector, both in vitro and in vivo, with the insertion of integrin-targeting peptide into the fiber.lld:pubmed
pubmed-article:15296099pubmed:affiliationDepartment of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Osaka University, Japan.lld:pubmed
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