| pubmed-article:1529527 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1529527 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:1529527 | lifeskim:mentions | umls-concept:C0035668 | lld:lifeskim |
| pubmed-article:1529527 | lifeskim:mentions | umls-concept:C0080125 | lld:lifeskim |
| pubmed-article:1529527 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:1529527 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:1529527 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:1529527 | lifeskim:mentions | umls-concept:C1514926 | lld:lifeskim |
| pubmed-article:1529527 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1529527 | pubmed:dateCreated | 1992-10-16 | lld:pubmed |
| pubmed-article:1529527 | pubmed:abstractText | A ribozyme was constructed that specifically cleaves RNA that contains the first coding exon of the tat gene of HIV-1. This anti-tat ribozyme was incorporated into a Moloney murine leukemia virus vector. A sequence containing only the 48-nucleotide antisense region of the ribozyme was also inserted into the retroviral vector. Human T-cell lines constitutively producing the tat-antisense and the anti-tat ribozyme RNA were created by transduction into Jurkat cells. When challenged with HIV-1, both the tat-antisense and anti-tat ribozyme-producing cells inhibited the replication of HIV-1. The antisense vector conferred a greater resistance to HIV-1 replication than did the anti-tat ribozyme vector. | lld:pubmed |
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| pubmed-article:1529527 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1529527 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1529527 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1529527 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1529527 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1529527 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:1529527 | pubmed:issn | 0042-6822 | lld:pubmed |
| pubmed-article:1529527 | pubmed:author | pubmed-author:HaseltineW... | lld:pubmed |
| pubmed-article:1529527 | pubmed:author | pubmed-author:PappII | lld:pubmed |
| pubmed-article:1529527 | pubmed:author | pubmed-author:GOBAA | lld:pubmed |
| pubmed-article:1529527 | pubmed:author | pubmed-author:DehniGG | lld:pubmed |
| pubmed-article:1529527 | pubmed:author | pubmed-author:BiasoloM AMA | lld:pubmed |
| pubmed-article:1529527 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1529527 | pubmed:volume | 190 | lld:pubmed |
| pubmed-article:1529527 | pubmed:geneSymbol | tat | lld:pubmed |
| pubmed-article:1529527 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1529527 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1529527 | pubmed:pagination | 176-83 | lld:pubmed |
| pubmed-article:1529527 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:1529527 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1529527 | pubmed:articleTitle | Inhibition of replication of HIV-1 by retroviral vectors expressing tat-antisense and anti-tat ribozyme RNA. | lld:pubmed |
| pubmed-article:1529527 | pubmed:affiliation | Division of Human Retrovirology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115. | lld:pubmed |
| pubmed-article:1529527 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1529527 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1529527 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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