| pubmed-article:15294161 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15294161 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:15294161 | lifeskim:mentions | umls-concept:C0010851 | lld:lifeskim |
| pubmed-article:15294161 | lifeskim:mentions | umls-concept:C0001271 | lld:lifeskim |
| pubmed-article:15294161 | lifeskim:mentions | umls-concept:C1513371 | lld:lifeskim |
| pubmed-article:15294161 | lifeskim:mentions | umls-concept:C0444930 | lld:lifeskim |
| pubmed-article:15294161 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:15294161 | pubmed:dateCreated | 2004-8-5 | lld:pubmed |
| pubmed-article:15294161 | pubmed:abstractText | Understanding how a particular cell type expresses the lamellipodial or filopodial form of the actin machinery is essential to understanding a cell's functional interactions. To determine how a cell "chooses" among these alternative modes of "molecular hardware," we tested the role of key proteins that affect actin filament barbed ends. Depletion of capping protein (CP) by short hairpin RNA (shRNA) caused loss of lamellipodia and explosive formation of filopodia. The knockdown phenotype was rescued by a CP mutant refractory to shRNA, but not by another barbed-end capper, gelsolin, demonstrating that the phenotype was specific for CP. In Ena/VASP deficient cells, CP depletion resulted in ruffling instead of filopodia. We propose a model for selection of lamellipodial versus filopodial organization in which CP is a negative regulator of filopodia formation and Ena/VASP has recruiting/activating functions downstream of actin filament elongation in addition to its previously suggested anticapping and antibranching activities. | lld:pubmed |
| pubmed-article:15294161 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15294161 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15294161 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15294161 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15294161 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15294161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15294161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15294161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15294161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15294161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15294161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15294161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15294161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15294161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15294161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15294161 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15294161 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:15294161 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:15294161 | pubmed:author | pubmed-author:GertlerFrank... | lld:pubmed |
| pubmed-article:15294161 | pubmed:author | pubmed-author:SvitkinaTatya... | lld:pubmed |
| pubmed-article:15294161 | pubmed:author | pubmed-author:BorisyGary... | lld:pubmed |
| pubmed-article:15294161 | pubmed:author | pubmed-author:KojimaShin-ic... | lld:pubmed |
| pubmed-article:15294161 | pubmed:author | pubmed-author:MejillanoMari... | lld:pubmed |
| pubmed-article:15294161 | pubmed:author | pubmed-author:ApplewhiteDer... | lld:pubmed |
| pubmed-article:15294161 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15294161 | pubmed:day | 6 | lld:pubmed |
| pubmed-article:15294161 | pubmed:volume | 118 | lld:pubmed |
| pubmed-article:15294161 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15294161 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15294161 | pubmed:pagination | 363-73 | lld:pubmed |
| pubmed-article:15294161 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:15294161 | pubmed:meshHeading | pubmed-meshheading:15294161... | lld:pubmed |
| pubmed-article:15294161 | pubmed:meshHeading | pubmed-meshheading:15294161... | lld:pubmed |
| pubmed-article:15294161 | pubmed:meshHeading | pubmed-meshheading:15294161... | lld:pubmed |
| pubmed-article:15294161 | pubmed:meshHeading | pubmed-meshheading:15294161... | lld:pubmed |
| pubmed-article:15294161 | pubmed:meshHeading | pubmed-meshheading:15294161... | lld:pubmed |
| pubmed-article:15294161 | pubmed:meshHeading | pubmed-meshheading:15294161... | lld:pubmed |
| pubmed-article:15294161 | pubmed:meshHeading | pubmed-meshheading:15294161... | lld:pubmed |
| pubmed-article:15294161 | pubmed:meshHeading | pubmed-meshheading:15294161... | lld:pubmed |
| pubmed-article:15294161 | pubmed:meshHeading | pubmed-meshheading:15294161... | lld:pubmed |
| pubmed-article:15294161 | pubmed:meshHeading | pubmed-meshheading:15294161... | lld:pubmed |
| pubmed-article:15294161 | pubmed:meshHeading | pubmed-meshheading:15294161... | lld:pubmed |
| pubmed-article:15294161 | pubmed:meshHeading | pubmed-meshheading:15294161... | lld:pubmed |
| pubmed-article:15294161 | pubmed:meshHeading | pubmed-meshheading:15294161... | lld:pubmed |
| pubmed-article:15294161 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15294161 | pubmed:articleTitle | Lamellipodial versus filopodial mode of the actin nanomachinery: pivotal role of the filament barbed end. | lld:pubmed |
| pubmed-article:15294161 | pubmed:affiliation | Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, 303 E. Chicago Avenue, Chicago, IL 60611, USA. | lld:pubmed |
| pubmed-article:15294161 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15294161 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15294161 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| entrez-gene:12345 | entrezgene:pubmed | pubmed-article:15294161 | lld:entrezgene |
| entrez-gene:14086 | entrezgene:pubmed | pubmed-article:15294161 | lld:entrezgene |
| entrez-gene:22323 | entrezgene:pubmed | pubmed-article:15294161 | lld:entrezgene |
| entrez-gene:56378 | entrezgene:pubmed | pubmed-article:15294161 | lld:entrezgene |
| entrez-gene:67771 | entrezgene:pubmed | pubmed-article:15294161 | lld:entrezgene |
| entrez-gene:227753 | entrezgene:pubmed | pubmed-article:15294161 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15294161 | lld:pubmed |
