| pubmed-article:15289445 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15289445 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:15289445 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:15289445 | lifeskim:mentions | umls-concept:C0003483 | lld:lifeskim |
| pubmed-article:15289445 | lifeskim:mentions | umls-concept:C0040711 | lld:lifeskim |
| pubmed-article:15289445 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:15289445 | lifeskim:mentions | umls-concept:C0020456 | lld:lifeskim |
| pubmed-article:15289445 | lifeskim:mentions | umls-concept:C0380603 | lld:lifeskim |
| pubmed-article:15289445 | lifeskim:mentions | umls-concept:C1512886 | lld:lifeskim |
| pubmed-article:15289445 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:15289445 | pubmed:dateCreated | 2004-10-6 | lld:pubmed |
| pubmed-article:15289445 | pubmed:abstractText | Fibroblast growth factor 2 (FGF-2) is normally synthesized at low levels but is elevated in various pathophysiological conditions including diabetes-associated vascular diseases. FGF-2 expression is regulated translationally through an internal ribosome entry site (IRES) located in its mRNA, which allows a nonclassical cap-independent translation. We addressed the pathophysiological regulation of the IRES in vivo by using a streptozotocin-induced hyperglycemic model known to suppress markedly overall translation. Evaluation of FGF-2 IRES-dependent translation was performed with transgenic mice expressing dual luciferase bicistronic mRNA containing the FGF-2 IRES. FGF-2 IRES-dependent reporter activity increased 240% of control in the diabetic aorta although the reporter mRNA levels significantly decreased. Expression of endogenous FGF-2 protein in the aorta closely correlated with the IRES activity but not with FGF-2 mRNA levels. Moreover, the biosynthesis of endogenous FGF-2 protein was stimulated in an IRES-dependent manner by high glucose that significantly suppressed global protein synthesis in aortic smooth muscle cells from the transgenic mice. These results suggest that IRES-dependent translational regulation could play a pathological role in FGF-2 expression in vivo, especially in the cardiovascular consequences of diabetes. | lld:pubmed |
| pubmed-article:15289445 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15289445 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15289445 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15289445 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15289445 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15289445 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15289445 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15289445 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:15289445 | pubmed:issn | 1530-6860 | lld:pubmed |
| pubmed-article:15289445 | pubmed:author | pubmed-author:RokutanKazuhi... | lld:pubmed |
| pubmed-article:15289445 | pubmed:author | pubmed-author:BayardFrancis... | lld:pubmed |
| pubmed-article:15289445 | pubmed:author | pubmed-author:KondoKazumiK | lld:pubmed |
| pubmed-article:15289445 | pubmed:author | pubmed-author:PratsAnne-Cat... | lld:pubmed |
| pubmed-article:15289445 | pubmed:author | pubmed-author:ArnalJean-Fra... | lld:pubmed |
| pubmed-article:15289445 | pubmed:author | pubmed-author:Teshima-Kondo... | lld:pubmed |
| pubmed-article:15289445 | pubmed:author | pubmed-author:Prado-Lourenc... | lld:pubmed |
| pubmed-article:15289445 | pubmed:author | pubmed-author:Gonzalez-Herr... | lld:pubmed |
| pubmed-article:15289445 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:15289445 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:15289445 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15289445 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15289445 | pubmed:pagination | 1583-5 | lld:pubmed |
| pubmed-article:15289445 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:15289445 | pubmed:meshHeading | pubmed-meshheading:15289445... | lld:pubmed |
| pubmed-article:15289445 | pubmed:meshHeading | pubmed-meshheading:15289445... | lld:pubmed |
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| pubmed-article:15289445 | pubmed:meshHeading | pubmed-meshheading:15289445... | lld:pubmed |
| pubmed-article:15289445 | pubmed:meshHeading | pubmed-meshheading:15289445... | lld:pubmed |
| pubmed-article:15289445 | pubmed:meshHeading | pubmed-meshheading:15289445... | lld:pubmed |
| pubmed-article:15289445 | pubmed:meshHeading | pubmed-meshheading:15289445... | lld:pubmed |
| pubmed-article:15289445 | pubmed:meshHeading | pubmed-meshheading:15289445... | lld:pubmed |
| pubmed-article:15289445 | pubmed:meshHeading | pubmed-meshheading:15289445... | lld:pubmed |
| pubmed-article:15289445 | pubmed:meshHeading | pubmed-meshheading:15289445... | lld:pubmed |
| pubmed-article:15289445 | pubmed:meshHeading | pubmed-meshheading:15289445... | lld:pubmed |
| pubmed-article:15289445 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15289445 | pubmed:articleTitle | Hyperglycemia upregulates translation of the fibroblast growth factor 2 mRNA in mouse aorta via internal ribosome entry site. | lld:pubmed |
| pubmed-article:15289445 | pubmed:affiliation | Institut National de la Santé et de la Recherche Médicale U589, Hormones, Facteurs de Croissance et Physiopathologie Vasculaire, Institut Louis Bugnard IFR31, Hôpital Rangueil, Toulouse, France. | lld:pubmed |
| pubmed-article:15289445 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15289445 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:14173 | entrezgene:pubmed | pubmed-article:15289445 | lld:entrezgene |
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