| pubmed-article:15288766 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15288766 | lifeskim:mentions | umls-concept:C0225336 | lld:lifeskim |
| pubmed-article:15288766 | lifeskim:mentions | umls-concept:C0014939 | lld:lifeskim |
| pubmed-article:15288766 | lifeskim:mentions | umls-concept:C0017428 | lld:lifeskim |
| pubmed-article:15288766 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:15288766 | pubmed:issue | 8-9 | lld:pubmed |
| pubmed-article:15288766 | pubmed:dateCreated | 2004-8-3 | lld:pubmed |
| pubmed-article:15288766 | pubmed:abstractText | Estrogen receptors act via the regulation of transcriptional processes, involving nuclear translocation and binding on specific response elements, thus leading to regulation of target gene expression. However, novel non-transcriptional mechanisms of signal transduction through steroid hormone receptors have been identified. These so-called "non-genomic" effects are independent by gene transcription or protein synthesis and involve steroid-induced modulation of cytoplasmic or of cell membrane-bound regulatory proteins. Relevant biological actions of steroids have been associated with this signaling in different tissues. Ubiquitary regulatory cascades such as mitogen-activated protein kinases (MAPK), the phosphatidylinositol 3-OH kinase (PI3K) and tyrosine kinases are modulated through non-transcriptional mechanisms by steroid hormones. Furthermore, steroid hormone receptors modulation of cell membrane-associated molecules such as ion channels and G-protein-coupled receptors has been shown in diverse tissues. The vascular wall is a site where non-genomic steroid hormones actions are particularly prominent. For instance, estrogens and glucocorticoids trigger rapid vasodilatation due to rapid induction of nitric oxide synthesis in endothelial cells via the estrogen receptor-dependent activation of MAPK and PI3K, leading to relevant pathophysiological consequences, in vitro and in vivo. The growing amount of evidence collected in the last years claims that non-transcriptional signaling mechanisms play a primary role in the generation of the effects of steroids on endothelial cells, which may turn out to be of relevance for clinical purposes. | lld:pubmed |
| pubmed-article:15288766 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15288766 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15288766 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15288766 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15288766 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:15288766 | pubmed:issn | 0039-128X | lld:pubmed |
| pubmed-article:15288766 | pubmed:author | pubmed-author:SimonciniTomm... | lld:pubmed |
| pubmed-article:15288766 | pubmed:author | pubmed-author:GenazzaniAndr... | lld:pubmed |
| pubmed-article:15288766 | pubmed:author | pubmed-author:VaroneGaetano... | lld:pubmed |
| pubmed-article:15288766 | pubmed:author | pubmed-author:FornariLetizi... | lld:pubmed |
| pubmed-article:15288766 | pubmed:author | pubmed-author:MannellaPaolo... | lld:pubmed |
| pubmed-article:15288766 | pubmed:author | pubmed-author:CarusoAntonel... | lld:pubmed |
| pubmed-article:15288766 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15288766 | pubmed:volume | 69 | lld:pubmed |
| pubmed-article:15288766 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15288766 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15288766 | pubmed:pagination | 537-42 | lld:pubmed |
| pubmed-article:15288766 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:15288766 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15288766 | pubmed:articleTitle | Genomic and non-genomic effects of estrogens on endothelial cells. | lld:pubmed |
| pubmed-article:15288766 | pubmed:affiliation | Molecular and Cellular Gynecological Endocrinology Laboratory (MCGEL), Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Via Roma 67, 56100 Pisa, Italy. t.simoncini@obgyn.med.unipi.it | lld:pubmed |
| pubmed-article:15288766 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15288766 | pubmed:publicationType | Review | lld:pubmed |
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