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pubmed-article:15288290pubmed:abstractTextThe aim of our study was to describe late failures in children who initially survived event-free five years from a diagnosis of rhabdomyosarcoma. Charts of children enrolled in the Intergroup Rhabdomyosarcoma Study Group (IRSG) trials III, IV pilot and IV (1984-1997) who survived five years event-free and subsequently experienced an adverse event (disease recurrence, second malignant neoplasm or death from other causes) were reviewed. Of the 2534 enrolled patients, 1160 were event-free at five years and 48 subsequently experienced a late event. The estimated 10-year event rate for the 1160 patients who were alive and event-free at five years was 9% (95% Confidence Interval (CI) 5%, 13%). Patients with both advanced disease (Group III/IV) and large primary tumours at diagnosis (> 5 cm) were at the highest risk for late events (19%; 95% CI 8%, 30%). Late events after successful treatment for rhabdomyosarcoma occur in 9%. Those with advanced disease and large primary tumours have the highest risk of late events.lld:pubmed
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pubmed-article:15288290pubmed:volume40lld:pubmed
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pubmed-article:15288290pubmed:pagination1878-85lld:pubmed
pubmed-article:15288290pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:15288290pubmed:year2004lld:pubmed
pubmed-article:15288290pubmed:articleTitleLate events occurring five years or more after successful therapy for childhood rhabdomyosarcoma: a report from the Soft Tissue Sarcoma Committee of the Children's Oncology Group.lld:pubmed
pubmed-article:15288290pubmed:affiliationThe Division of Hematology/Oncology, Hospital for Sick Children, 555 University Avenue, Toronto, Ont., M5G 1X8, Canada.lld:pubmed
pubmed-article:15288290pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15288290pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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