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pubmed-article:1528271pubmed:abstractTextAfter inhibition of extraneuronal uptake by corticosterone, isolated right atria and lengthwise halved vasa deferentia of the rat were incubated with 0.2 mumol/l 3H-noradrenaline for 60 min, washed out for 100 min and then prepared for autoradiography. The autoradiographic images were digitized, and silver grain density was determined as a function of the distance from the surface. Silver grain density declined towards the centre of the tissue; the decline was monophasic exponential and significantly steeper in the vas deferens (0.016 microns-1) than in the less densely innervated right atrium (0.011 microns-1). Silver grain density at the surface of the tissue was higher in vas deferens than in right atrium. The results show that the extracellular steady-state concentration gradient for 3H-noradrenaline (generated by uptake1 during the incubation with this amine) largely depends on the density of the adrenergic innervation.lld:pubmed
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pubmed-article:1528271pubmed:authorpubmed-author:SchömigEElld:pubmed
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pubmed-article:1528271pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:1528271pubmed:year1992lld:pubmed
pubmed-article:1528271pubmed:articleTitleThe influence of the density of adrenergic innervation on the extracellular steady-state concentration gradient for 3H-noradrenaline.lld:pubmed
pubmed-article:1528271pubmed:affiliationInstitut für Pharmakologie und Toxikologie, Universität Würzburg, Federal Republic of Germany.lld:pubmed
pubmed-article:1528271pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:1528271pubmed:publicationTypeIn Vitrolld:pubmed
pubmed-article:1528271pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed