| pubmed-article:15282297 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15282297 | lifeskim:mentions | umls-concept:C0024501 | lld:lifeskim |
| pubmed-article:15282297 | lifeskim:mentions | umls-concept:C1366876 | lld:lifeskim |
| pubmed-article:15282297 | lifeskim:mentions | umls-concept:C1833235 | lld:lifeskim |
| pubmed-article:15282297 | lifeskim:mentions | umls-concept:C1819882 | lld:lifeskim |
| pubmed-article:15282297 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:15282297 | lifeskim:mentions | umls-concept:C0205100 | lld:lifeskim |
| pubmed-article:15282297 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:15282297 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:15282297 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:15282297 | pubmed:dateCreated | 2004-7-29 | lld:pubmed |
| pubmed-article:15282297 | pubmed:abstractText | In anergic T cells, T-cell receptor (TCR)-mediated responses are functionally inactivated by negative regulatory signals whose mechanisms are poorly understood. Here, we show that CD4(+) T cells anergized in vivo by superantigen Mls-1(a) express a scaffolding protein, transforming growth factor beta-activated protein kinase 1-binding protein 1 (TAB1), that negatively regulates TCR signaling through the activation of mitogen-activated protein kinase p38 alpha. TAB1 was not expressed in naive and activated CD4(+) T cells. Inhibition of p38 activity in anergic T cells by a chemical inhibitor resulted in the recovery of interleukin 2 (IL-2) and the inhibition of IL-10 secretion. T-cell hybridoma 2B4 cells transduced with TAB1-containing retrovirus (TAB1-2B4 cells) showed activated p38 alpha, inhibited extracellular signal-regulated kinase (ERK) activity, culminating in reduced IL-2 levels and increased IL-10 production. The use of a p38 inhibitor or cotransfection of a dominant-negative form of p38 in TAB1-2B4 cells resulted in the recovery of ERK activity and IL-2 production. These results imply that TAB1-mediated activation of p38 alpha in anergic T cells regulates the maintenance of T-cell unresponsiveness both by inhibiting IL-2 production and by promoting IL-10 production. | lld:pubmed |
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| pubmed-article:15282297 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15282297 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15282297 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15282297 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15282297 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:15282297 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:15282297 | pubmed:author | pubmed-author:YuiKatsuyukiK | lld:pubmed |
| pubmed-article:15282297 | pubmed:author | pubmed-author:UdonoHeiichir... | lld:pubmed |
| pubmed-article:15282297 | pubmed:author | pubmed-author:TominagaNorio... | lld:pubmed |
| pubmed-article:15282297 | pubmed:author | pubmed-author:Ohkusu-Tsukad... | lld:pubmed |
| pubmed-article:15282297 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15282297 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:15282297 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15282297 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15282297 | pubmed:pagination | 6957-66 | lld:pubmed |
| pubmed-article:15282297 | pubmed:dateRevised | 2011-10-14 | lld:pubmed |
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