| pubmed-article:15279958 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15279958 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:15279958 | lifeskim:mentions | umls-concept:C0032150 | lld:lifeskim |
| pubmed-article:15279958 | lifeskim:mentions | umls-concept:C0968147 | lld:lifeskim |
| pubmed-article:15279958 | lifeskim:mentions | umls-concept:C1519249 | lld:lifeskim |
| pubmed-article:15279958 | lifeskim:mentions | umls-concept:C0599894 | lld:lifeskim |
| pubmed-article:15279958 | lifeskim:mentions | umls-concept:C2700116 | lld:lifeskim |
| pubmed-article:15279958 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15279958 | pubmed:dateCreated | 2004-7-28 | lld:pubmed |
| pubmed-article:15279958 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15279958 | pubmed:abstractText | The intraerythrocytic stages of Plasmodium falciparum are exposed to oxidative stress and require functional anti-oxidant systems to survive. In addition to the parasite's known iron-dependent superoxide dismutase PfSOD1, a second SOD gene (PfSOD2) interrupted by 8 introns was identified on chromosome 6. Molecular modelling shows that the structure of PfSOD2 is similar to other iron-dependent SODs and phylogenetic analysis suggests PfSOD1 and PfSOD2 are the result of an ancestral gene duplication. The deduced amino acid sequence of PfSOD2 is similar to PfSOD1 but has a long N-terminal extension. Immunofluorescence studies show that PfSOD1 is cytosolic, whereas the N-terminal extension of PfSOD2 targets a green fluorescent protein fusion into the parasite's mitochondrion. Both SOD genes are transcribed during the erythrocytic cycle with PfSOD1 mRNA levels up to 35-fold higher than those of PfSOD2. Northern blots demonstrated that the mRNA levels of both SOD genes are up-regulated upon exposure to oxidative stress. | lld:pubmed |
| pubmed-article:15279958 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15279958 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15279958 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15279958 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15279958 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15279958 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15279958 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15279958 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15279958 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15279958 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15279958 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15279958 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15279958 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15279958 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:15279958 | pubmed:issn | 0166-6851 | lld:pubmed |
| pubmed-article:15279958 | pubmed:author | pubmed-author:WrengerCarste... | lld:pubmed |
| pubmed-article:15279958 | pubmed:author | pubmed-author:WintjensRenéR | lld:pubmed |
| pubmed-article:15279958 | pubmed:author | pubmed-author:DiveDanielD | lld:pubmed |
| pubmed-article:15279958 | pubmed:author | pubmed-author:MüllerSylkeS | lld:pubmed |
| pubmed-article:15279958 | pubmed:author | pubmed-author:ViscogliosiEr... | lld:pubmed |
| pubmed-article:15279958 | pubmed:author | pubmed-author:CapronMonique... | lld:pubmed |
| pubmed-article:15279958 | pubmed:author | pubmed-author:KhalifeJamalJ | lld:pubmed |
| pubmed-article:15279958 | pubmed:author | pubmed-author:DaherWassimW | lld:pubmed |
| pubmed-article:15279958 | pubmed:author | pubmed-author:SienkiewiczNa... | lld:pubmed |
| pubmed-article:15279958 | pubmed:author | pubmed-author:JouinHelèneH | lld:pubmed |
| pubmed-article:15279958 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15279958 | pubmed:volume | 137 | lld:pubmed |
| pubmed-article:15279958 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15279958 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15279958 | pubmed:pagination | 121-32 | lld:pubmed |
| pubmed-article:15279958 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:15279958 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15279958 | pubmed:articleTitle | Identification of a mitochondrial superoxide dismutase with an unusual targeting sequence in Plasmodium falciparum. | lld:pubmed |
| pubmed-article:15279958 | pubmed:affiliation | Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, WTB/MSI Complex, DD15EH, UK. | lld:pubmed |
| pubmed-article:15279958 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15279958 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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