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| pubmed-article:15274919 | lifeskim:mentions | umls-concept:C0266463 | lld:lifeskim |
| pubmed-article:15274919 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:15274919 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:15274919 | lifeskim:mentions | umls-concept:C1418245 | lld:lifeskim |
| pubmed-article:15274919 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:15274919 | lifeskim:mentions | umls-concept:C1883221 | lld:lifeskim |
| pubmed-article:15274919 | lifeskim:mentions | umls-concept:C1514468 | lld:lifeskim |
| pubmed-article:15274919 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:15274919 | lifeskim:mentions | umls-concept:C1883204 | lld:lifeskim |
| pubmed-article:15274919 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
| pubmed-article:15274919 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:15274919 | pubmed:dateCreated | 2004-7-27 | lld:pubmed |
| pubmed-article:15274919 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15274919 | pubmed:abstractText | Mutations in the Lis1 gene result in lissencephaly (smooth brain), a debilitating developmental syndrome caused by the impaired ability of postmitotic neurons to migrate to their correct destination in the cerebral cortex. Sequence similarities suggest that the LIS1 protein contains a C-terminal seven-blade beta-propeller domain, while the structure of the N-terminal fragment includes the LisH (Lis-homology) motif, a pattern found in over 100 eukaryotic proteins with a hitherto unknown function. We present the 1.75 A resolution crystal structure of the N-terminal domain of mouse LIS1, and we show that the LisH motif is a novel, thermodynamically very stable dimerization domain. The structure explains the molecular basis of a low severity form of lissencephaly. | lld:pubmed |
| pubmed-article:15274919 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15274919 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15274919 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15274919 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15274919 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15274919 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15274919 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15274919 | pubmed:issn | 0969-2126 | lld:pubmed |
| pubmed-article:15274919 | pubmed:author | pubmed-author:CooperDavid... | lld:pubmed |
| pubmed-article:15274919 | pubmed:author | pubmed-author:DevedjievYanc... | lld:pubmed |
| pubmed-article:15274919 | pubmed:author | pubmed-author:DerewendaUrsz... | lld:pubmed |
| pubmed-article:15274919 | pubmed:author | pubmed-author:DerewendaZygm... | lld:pubmed |
| pubmed-article:15274919 | pubmed:author | pubmed-author:ReinerOrlyO | lld:pubmed |
| pubmed-article:15274919 | pubmed:author | pubmed-author:OtlewskiJacek... | lld:pubmed |
| pubmed-article:15274919 | pubmed:author | pubmed-author:KimMyung... | lld:pubmed |
| pubmed-article:15274919 | pubmed:author | pubmed-author:OleksyArkadiu... | lld:pubmed |
| pubmed-article:15274919 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15274919 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:15274919 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15274919 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15274919 | pubmed:pagination | 987-98 | lld:pubmed |
| pubmed-article:15274919 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:15274919 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15274919 | pubmed:articleTitle | The structure of the N-terminal domain of the product of the lissencephaly gene Lis1 and its functional implications. | lld:pubmed |
| pubmed-article:15274919 | pubmed:affiliation | Department of Molecular Physiology and Biological Physics and Cancer Center, University of Virginia, Charlottesville, VA 22908, USA. | lld:pubmed |
| pubmed-article:15274919 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15274919 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15274919 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:15274919 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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