| pubmed-article:15271349 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15271349 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:15271349 | lifeskim:mentions | umls-concept:C0220806 | lld:lifeskim |
| pubmed-article:15271349 | lifeskim:mentions | umls-concept:C0596843 | lld:lifeskim |
| pubmed-article:15271349 | lifeskim:mentions | umls-concept:C0034814 | lld:lifeskim |
| pubmed-article:15271349 | lifeskim:mentions | umls-concept:C0314603 | lld:lifeskim |
| pubmed-article:15271349 | lifeskim:mentions | umls-concept:C0175727 | lld:lifeskim |
| pubmed-article:15271349 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:15271349 | pubmed:dateCreated | 2004-7-23 | lld:pubmed |
| pubmed-article:15271349 | pubmed:abstractText | A large collection of bioactive compounds with diverse biological effects can be used as probes to elucidate new biological mechanisms that influence a particular cellular process. Here we analyze the effects of 880 well-known small-molecule bioactives or drugs on the insulin-induced adipogenesis of 3T3-L1 fibroblasts, a cell-culture model of fat cell differentiation. Our screen identified 86 compounds as modulators of the adipogenic differentiation of 3T3-L1 cells. Examination of their chemical and pharmacological information revealed that antihistamine drugs with distinct chemical scaffolds inhibit differentiation. Histamine H1 receptor is expressed in 3T3-L1 cells, and its knockdown by small interfering RNA impaired the insulin-induced adipogenic differentiation. Histamine receptors and histamine-like biogenic amines may play a role in inducing adipogenesis in response to insulin. | lld:pubmed |
| pubmed-article:15271349 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15271349 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15271349 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15271349 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15271349 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15271349 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15271349 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15271349 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15271349 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15271349 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15271349 | pubmed:issn | 1074-5521 | lld:pubmed |
| pubmed-article:15271349 | pubmed:author | pubmed-author:TanakaSatoshi... | lld:pubmed |
| pubmed-article:15271349 | pubmed:author | pubmed-author:UesugiMotonar... | lld:pubmed |
| pubmed-article:15271349 | pubmed:author | pubmed-author:KawazoeYoshin... | lld:pubmed |
| pubmed-article:15271349 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15271349 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:15271349 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15271349 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15271349 | pubmed:pagination | 907-13 | lld:pubmed |
| pubmed-article:15271349 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:15271349 | pubmed:meshHeading | pubmed-meshheading:15271349... | lld:pubmed |
| pubmed-article:15271349 | pubmed:meshHeading | pubmed-meshheading:15271349... | lld:pubmed |
| pubmed-article:15271349 | pubmed:meshHeading | pubmed-meshheading:15271349... | lld:pubmed |
| pubmed-article:15271349 | pubmed:meshHeading | pubmed-meshheading:15271349... | lld:pubmed |
| pubmed-article:15271349 | pubmed:meshHeading | pubmed-meshheading:15271349... | lld:pubmed |
| pubmed-article:15271349 | pubmed:meshHeading | pubmed-meshheading:15271349... | lld:pubmed |
| pubmed-article:15271349 | pubmed:meshHeading | pubmed-meshheading:15271349... | lld:pubmed |
| pubmed-article:15271349 | pubmed:meshHeading | pubmed-meshheading:15271349... | lld:pubmed |
| pubmed-article:15271349 | pubmed:meshHeading | pubmed-meshheading:15271349... | lld:pubmed |
| pubmed-article:15271349 | pubmed:meshHeading | pubmed-meshheading:15271349... | lld:pubmed |
| pubmed-article:15271349 | pubmed:meshHeading | pubmed-meshheading:15271349... | lld:pubmed |
| pubmed-article:15271349 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15271349 | pubmed:articleTitle | Chemical genetic identification of the histamine H1 receptor as a stimulator of insulin-induced adipogenesis. | lld:pubmed |
| pubmed-article:15271349 | pubmed:affiliation | The Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA. | lld:pubmed |
| pubmed-article:15271349 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15271349 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:15271349 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15271349 | lld:pubmed |
