| pubmed-article:15265595 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15265595 | lifeskim:mentions | umls-concept:C0025936 | lld:lifeskim |
| pubmed-article:15265595 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:15265595 | lifeskim:mentions | umls-concept:C0302600 | lld:lifeskim |
| pubmed-article:15265595 | lifeskim:mentions | umls-concept:C0228174 | lld:lifeskim |
| pubmed-article:15265595 | lifeskim:mentions | umls-concept:C0002726 | lld:lifeskim |
| pubmed-article:15265595 | lifeskim:mentions | umls-concept:C0221099 | lld:lifeskim |
| pubmed-article:15265595 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15265595 | pubmed:dateCreated | 2004-7-21 | lld:pubmed |
| pubmed-article:15265595 | pubmed:abstractText | Abeta peptides are naturally occurring peptides, which are thought to play a key role in the pathophysiology of Alzheimer's disease (AD). In AD cases, levels of soluble and insoluble Abeta peptides increase in the brain as well as in the cerebrovasculature, a phenomenon that does not occur in extra-cranial vessels. There are frequently anomalies in the cerebrovasculature in AD, and despite increases in several pro-angiogenic factors in AD brain, evidence for increased vascularity is lacking; in fact there is evidence to the contrary. It has also been recently shown that Abeta peptides may have profound anti-angiogenic effects in vitro and in vivo. We therefore investigated whether there is evidence for altered angiogenesis in the vasculature in a transgenic mouse model of Abeta amyloidosis (Tg APPsw line 2576). In vitro, the formation of capillary-like structures on a reconstituted extracellular matrix by endothelial cells isolated from Tg APPsw is impaired. Ex vivo, the sprouting of new capillaries from arterial explants (over expressing Abeta) isolated from 9-month-old Tg APPsw is reduced compared to arterial explants isolated from control littermates. In addition, Tg APPsw mice show a reduction in vascular density in the cortex and hippocampus compared to control littermates. Altogether, our data suggest that the over expression of APPsw in the vasculature may oppose angiogenesis. | lld:pubmed |
| pubmed-article:15265595 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15265595 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15265595 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15265595 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15265595 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15265595 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15265595 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15265595 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15265595 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15265595 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:15265595 | pubmed:issn | 0304-3940 | lld:pubmed |
| pubmed-article:15265595 | pubmed:author | pubmed-author:DelleDonneAnt... | lld:pubmed |
| pubmed-article:15265595 | pubmed:author | pubmed-author:MullanMichael... | lld:pubmed |
| pubmed-article:15265595 | pubmed:author | pubmed-author:ParisDanielD | lld:pubmed |
| pubmed-article:15265595 | pubmed:author | pubmed-author:SmeedRobertR | lld:pubmed |
| pubmed-article:15265595 | pubmed:author | pubmed-author:QuadrosAmitaA | lld:pubmed |
| pubmed-article:15265595 | pubmed:author | pubmed-author:PatelNikunjN | lld:pubmed |
| pubmed-article:15265595 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15265595 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:15265595 | pubmed:volume | 366 | lld:pubmed |
| pubmed-article:15265595 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15265595 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15265595 | pubmed:pagination | 80-5 | lld:pubmed |
| pubmed-article:15265595 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:15265595 | pubmed:meshHeading | pubmed-meshheading:15265595... | lld:pubmed |
| pubmed-article:15265595 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15265595 | pubmed:articleTitle | Impaired angiogenesis in a transgenic mouse model of cerebral amyloidosis. | lld:pubmed |
| pubmed-article:15265595 | pubmed:affiliation | The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA. dparis@rdfn.org | lld:pubmed |
| pubmed-article:15265595 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15265595 | pubmed:publicationType | In Vitro | lld:pubmed |
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