| pubmed-article:15261845 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15261845 | lifeskim:mentions | umls-concept:C0001811 | lld:lifeskim |
| pubmed-article:15261845 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:15261845 | lifeskim:mentions | umls-concept:C0024660 | lld:lifeskim |
| pubmed-article:15261845 | lifeskim:mentions | umls-concept:C0021641 | lld:lifeskim |
| pubmed-article:15261845 | lifeskim:mentions | umls-concept:C0021665 | lld:lifeskim |
| pubmed-article:15261845 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:15261845 | pubmed:dateCreated | 2004-7-20 | lld:pubmed |
| pubmed-article:15261845 | pubmed:abstractText | Research with invertebrates over the past 10 years has suggested that alterations in insulin and/or insulin-like growth factor I (IGF-I) signalling result in increased lifespan and retard ageing. In this chapter, we describe the current research in mammalian systems with respect to the role of insulin or IGF-I in ageing. Using rodent models of caloric restriction and genetic mouse models, e.g. the Ames and Snell dwarf mice, fat-specific insulin receptor knockout mice (FIRKO) and mice that are heterozygous for the IGF-I receptor (Igf1r+/-), investigators have shown that a reduction in plasma levels of insulin and/or IGF-I or reductions in insulin/IGF-I signalling appear to be correlated with increased longevity and retarded ageing. | lld:pubmed |
| pubmed-article:15261845 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15261845 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15261845 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15261845 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15261845 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15261845 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15261845 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15261845 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15261845 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:15261845 | pubmed:issn | 1521-690X | lld:pubmed |
| pubmed-article:15261845 | pubmed:author | pubmed-author:FahdS DSD | lld:pubmed |
| pubmed-article:15261845 | pubmed:author | pubmed-author:AdamoMartin... | lld:pubmed |
| pubmed-article:15261845 | pubmed:author | pubmed-author:NelsonJames... | lld:pubmed |
| pubmed-article:15261845 | pubmed:author | pubmed-author:RichardsonArl... | lld:pubmed |
| pubmed-article:15261845 | pubmed:author | pubmed-author:Van... | lld:pubmed |
| pubmed-article:15261845 | pubmed:copyrightInfo | Copyright 2004 Elsevier Ltd. | lld:pubmed |
| pubmed-article:15261845 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15261845 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:15261845 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15261845 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15261845 | pubmed:pagination | 393-406 | lld:pubmed |
| pubmed-article:15261845 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:15261845 | pubmed:meshHeading | pubmed-meshheading:15261845... | lld:pubmed |
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| pubmed-article:15261845 | pubmed:meshHeading | pubmed-meshheading:15261845... | lld:pubmed |
| pubmed-article:15261845 | pubmed:meshHeading | pubmed-meshheading:15261845... | lld:pubmed |
| pubmed-article:15261845 | pubmed:meshHeading | pubmed-meshheading:15261845... | lld:pubmed |
| pubmed-article:15261845 | pubmed:meshHeading | pubmed-meshheading:15261845... | lld:pubmed |
| pubmed-article:15261845 | pubmed:meshHeading | pubmed-meshheading:15261845... | lld:pubmed |
| pubmed-article:15261845 | pubmed:meshHeading | pubmed-meshheading:15261845... | lld:pubmed |
| pubmed-article:15261845 | pubmed:meshHeading | pubmed-meshheading:15261845... | lld:pubmed |
| pubmed-article:15261845 | pubmed:meshHeading | pubmed-meshheading:15261845... | lld:pubmed |
| pubmed-article:15261845 | pubmed:meshHeading | pubmed-meshheading:15261845... | lld:pubmed |
| pubmed-article:15261845 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15261845 | pubmed:articleTitle | The role of insulin and insulin-like growth factor-I in mammalian ageing. | lld:pubmed |
| pubmed-article:15261845 | pubmed:affiliation | Department of Cellular and Structural Biology, Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, 78229, USA. richardsona@uthscsa.edu | lld:pubmed |
| pubmed-article:15261845 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15261845 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15261845 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:15261845 | pubmed:publicationType | Review | lld:pubmed |
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