| pubmed-article:15247916 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15247916 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:15247916 | lifeskim:mentions | umls-concept:C0011854 | lld:lifeskim |
| pubmed-article:15247916 | lifeskim:mentions | umls-concept:C0126732 | lld:lifeskim |
| pubmed-article:15247916 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:15247916 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:15247916 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:15247916 | lifeskim:mentions | umls-concept:C1539897 | lld:lifeskim |
| pubmed-article:15247916 | lifeskim:mentions | umls-concept:C1516451 | lld:lifeskim |
| pubmed-article:15247916 | lifeskim:mentions | umls-concept:C1514623 | lld:lifeskim |
| pubmed-article:15247916 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:15247916 | pubmed:dateCreated | 2004-7-30 | lld:pubmed |
| pubmed-article:15247916 | pubmed:abstractText | Previous studies have suggested more than 20 genetic intervals that are associated with susceptibility to type 1 diabetes (T1D), but identification of specific genes has been challenging and largely limited to known candidate genes. Here, we report evidence for an association between T1D and multiple single-nucleotide polymorphisms in 197 kb of genomic DNA in the IDDM5 interval. We cloned a new gene (SUMO4), encoding small ubiquitin-like modifier 4 protein, in the interval. A substitution (M55V) at an evolutionarily conserved residue of the crucial CUE domain of SUMO4 was strongly associated with T1D (P = 1.9 x 10(-7)). SUMO4 conjugates to I kappa B alpha and negatively regulates NF kappa B transcriptional activity. The M55V substitution resulted in 5.5 times greater NF kappa B transcriptional activity and approximately 2 times greater expression of IL12B, an NF kappa B-dependent gene. These findings suggest a new pathway that may be implicated in the pathogenesis of T1D. | lld:pubmed |
| pubmed-article:15247916 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15247916 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15247916 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15247916 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15247916 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15247916 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15247916 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15247916 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15247916 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15247916 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:15247916 | pubmed:issn | 1061-4036 | lld:pubmed |
| pubmed-article:15247916 | pubmed:author | pubmed-author:YangPingP | lld:pubmed |
| pubmed-article:15247916 | pubmed:author | pubmed-author:ZhangYanY | lld:pubmed |
| pubmed-article:15247916 | pubmed:author | pubmed-author:RotterJerome... | lld:pubmed |
| pubmed-article:15247916 | pubmed:author | pubmed-author:AtkinsonMarkM | lld:pubmed |
| pubmed-article:15247916 | pubmed:author | pubmed-author:SheJin-XiongJ... | lld:pubmed |
| pubmed-article:15247916 | pubmed:author | pubmed-author:Serrano-RiosM... | lld:pubmed |
| pubmed-article:15247916 | pubmed:author | pubmed-author:DongZhengZ | lld:pubmed |
| pubmed-article:15247916 | pubmed:author | pubmed-author:BachJean-Fran... | lld:pubmed |
| pubmed-article:15247916 | pubmed:author | pubmed-author:PozzilliPaolo... | lld:pubmed |
| pubmed-article:15247916 | pubmed:author | pubmed-author:MuirAndrewA | lld:pubmed |
| pubmed-article:15247916 | pubmed:author | pubmed-author:GarchonHenri-... | lld:pubmed |
| pubmed-article:15247916 | pubmed:author | pubmed-author:RaffelLeslie... | lld:pubmed |
| pubmed-article:15247916 | pubmed:author | pubmed-author:EckenrodeSara... | lld:pubmed |
| pubmed-article:15247916 | pubmed:author | pubmed-author:HopkinsDianeD | lld:pubmed |
| pubmed-article:15247916 | pubmed:author | pubmed-author:ZhangZixinZ | lld:pubmed |
| pubmed-article:15247916 | pubmed:author | pubmed-author:BruskoToddT | lld:pubmed |
| pubmed-article:15247916 | pubmed:author | pubmed-author:WangCong-YiCY | lld:pubmed |
| pubmed-article:15247916 | pubmed:author | pubmed-author:JacobChaim... | lld:pubmed |
| pubmed-article:15247916 | pubmed:author | pubmed-author:WangJinzhaoJ | lld:pubmed |
| pubmed-article:15247916 | pubmed:author | pubmed-author:ParkYongsooY | lld:pubmed |
| pubmed-article:15247916 | pubmed:author | pubmed-author:PurohitSharad... | lld:pubmed |
| pubmed-article:15247916 | pubmed:author | pubmed-author:GuoDehuangD | lld:pubmed |
| pubmed-article:15247916 | pubmed:author | pubmed-author:ZhengWeipengW | lld:pubmed |
| pubmed-article:15247916 | pubmed:author | pubmed-author:LiManyuM | lld:pubmed |
| pubmed-article:15247916 | pubmed:author | pubmed-author:PodolskyRober... | lld:pubmed |
| pubmed-article:15247916 | pubmed:author | pubmed-author:ZeidlerAdinaA | lld:pubmed |
| pubmed-article:15247916 | pubmed:author | pubmed-author:LarradMaria... | lld:pubmed |
| pubmed-article:15247916 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15247916 | pubmed:volume | 36 | lld:pubmed |
| pubmed-article:15247916 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15247916 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15247916 | pubmed:pagination | 837-41 | lld:pubmed |
| pubmed-article:15247916 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:15247916 | pubmed:meshHeading | pubmed-meshheading:15247916... | lld:pubmed |
| pubmed-article:15247916 | pubmed:meshHeading | pubmed-meshheading:15247916... | lld:pubmed |
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| pubmed-article:15247916 | pubmed:meshHeading | pubmed-meshheading:15247916... | lld:pubmed |
| pubmed-article:15247916 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15247916 | pubmed:articleTitle | A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes. | lld:pubmed |
| pubmed-article:15247916 | pubmed:affiliation | Center for Biotechnology and Genomic Medicine, Medical College of Georgia, 1120 15th Street, CA4098, Augusta, Georgia 30912, USA. | lld:pubmed |
| pubmed-article:15247916 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15247916 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15247916 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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