| pubmed-article:15246364 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15246364 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
| pubmed-article:15246364 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:15246364 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:15246364 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:15246364 | lifeskim:mentions | umls-concept:C0035412 | lld:lifeskim |
| pubmed-article:15246364 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:15246364 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:15246364 | lifeskim:mentions | umls-concept:C0040399 | lld:lifeskim |
| pubmed-article:15246364 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:15246364 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:15246364 | lifeskim:mentions | umls-concept:C1522485 | lld:lifeskim |
| pubmed-article:15246364 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:15246364 | pubmed:dateCreated | 2004-7-12 | lld:pubmed |
| pubmed-article:15246364 | pubmed:abstractText | [125I]-2-iodo-L-phenylalanine, a new radioiodinated phenylalanine analog was evaluated as a potential specific tumor tracer for SPECT. The tracer is obtained with an overall radiochemical yield of at least 98%, a purity of > 99%, and a specific activity of 11 MBq/mmol in one pot Kit conditions using the Cu1+ assisted isotopic exchange. The tracer is evaluated in vitro using R1M rat rabdomyosarcoma cells in HEPES buffer with and without Na+ ions and in MEM buffer. The uptake of [125I]-2-iodo-L-phenylalanine follows a reversible pseudo-first-order reaction which is the same in presence and absence of Na+ ions, but the compound is not incorporated into the cell proteins. The reversible uptake is proven to occur with the same affinity as L-henylalanine by a saturable transport system which is competitively inhibited by BCH, an L transport type selective molecule. Trans-stimulation of the efflux by BCH and typical L transported amino acids shows that the transporter is of the antiport type and fulfils all the properties of the LAT1 heterodimer transport system. [125I]-2-iodo-L-phenylalanine is thus a phenylalanine analog that for the uptake uses for the major part the LAT1 transport system which is known to be over-expressed in tumor cells. This, together with the easy Kit preparation, makes [123I]-2-iodo-L-phenylalanine a promising tumor specific tracer for SPECT. | lld:pubmed |
| pubmed-article:15246364 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15246364 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15246364 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15246364 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15246364 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15246364 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15246364 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15246364 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15246364 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15246364 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:15246364 | pubmed:issn | 0969-8051 | lld:pubmed |
| pubmed-article:15246364 | pubmed:author | pubmed-author:BossuytAA | lld:pubmed |
| pubmed-article:15246364 | pubmed:author | pubmed-author:MertensJJ | lld:pubmed |
| pubmed-article:15246364 | pubmed:author | pubmed-author:BauwensMM | lld:pubmed |
| pubmed-article:15246364 | pubmed:author | pubmed-author:SlegersGG | lld:pubmed |
| pubmed-article:15246364 | pubmed:author | pubmed-author:JoosCC | lld:pubmed |
| pubmed-article:15246364 | pubmed:author | pubmed-author:LahoutteTT | lld:pubmed |
| pubmed-article:15246364 | pubmed:author | pubmed-author:KersemansVV | lld:pubmed |
| pubmed-article:15246364 | pubmed:copyrightInfo | Copyright 2004 Elsevier Inc. | lld:pubmed |
| pubmed-article:15246364 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15246364 | pubmed:volume | 31 | lld:pubmed |
| pubmed-article:15246364 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15246364 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15246364 | pubmed:pagination | 739-46 | lld:pubmed |
| pubmed-article:15246364 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:15246364 | pubmed:meshHeading | pubmed-meshheading:15246364... | lld:pubmed |
| pubmed-article:15246364 | pubmed:meshHeading | pubmed-meshheading:15246364... | lld:pubmed |
| pubmed-article:15246364 | pubmed:meshHeading | pubmed-meshheading:15246364... | lld:pubmed |
| pubmed-article:15246364 | pubmed:meshHeading | pubmed-meshheading:15246364... | lld:pubmed |
| pubmed-article:15246364 | pubmed:meshHeading | pubmed-meshheading:15246364... | lld:pubmed |
| pubmed-article:15246364 | pubmed:meshHeading | pubmed-meshheading:15246364... | lld:pubmed |
| pubmed-article:15246364 | pubmed:meshHeading | pubmed-meshheading:15246364... | lld:pubmed |
| pubmed-article:15246364 | pubmed:meshHeading | pubmed-meshheading:15246364... | lld:pubmed |
| pubmed-article:15246364 | pubmed:meshHeading | pubmed-meshheading:15246364... | lld:pubmed |
| pubmed-article:15246364 | pubmed:meshHeading | pubmed-meshheading:15246364... | lld:pubmed |
| pubmed-article:15246364 | pubmed:meshHeading | pubmed-meshheading:15246364... | lld:pubmed |
| pubmed-article:15246364 | pubmed:meshHeading | pubmed-meshheading:15246364... | lld:pubmed |
| pubmed-article:15246364 | pubmed:meshHeading | pubmed-meshheading:15246364... | lld:pubmed |
| pubmed-article:15246364 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15246364 | pubmed:articleTitle | Synthesis, radiosynthesis, and in vitro characterization of [125I]-2- iodo-L-phenylalanine in a R1M rhabdomyosarcoma cell model as a new potential tumor tracer for SPECT. | lld:pubmed |
| pubmed-article:15246364 | pubmed:affiliation | Nuclear Medicine Department/BEFY, Vrije Universiteit Brussel, Belgium. jjmerten@vub.ac.be | lld:pubmed |
| pubmed-article:15246364 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15246364 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
