| pubmed-article:15246265 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15246265 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:15246265 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:15246265 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:15246265 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:15246265 | lifeskim:mentions | umls-concept:C0301625 | lld:lifeskim |
| pubmed-article:15246265 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:15246265 | pubmed:dateCreated | 2004-7-12 | lld:pubmed |
| pubmed-article:15246265 | pubmed:abstractText | We investigated the effects of signaling through CD28 family molecules on human immunodeficiency virus type 1 (HIV-1) replication in vitro. A monoclonal antibody (mAb) specific for inducible costimulator (ICOS) suppressed both X4 and R5 HIV-1 replication in CD4(+) peripheral blood mononuclear cells (PBMC). This suppression was not attributable to reduced cell growth or viability. CD28 mAb showed variable effects and also suppressed HIV-1 replication when immobilized. Replication of pseudotype viruses with HIV-1-but not with vesicular stomatitis virus G-envelope was efficiently suppressed in CD4(+) PBMC treated with ICOS or CD28 mAbs. However, CD4, CXCR4, and CCR5 expression on the surface was not down-regulated. Moreover, HIV-1 replication in CD4(+) PBMC was suppressed by a soluble form of human B7-H2, a ligand of ICOS, but was enhanced by soluble B7-1, a ligand for CD28. These findings suggest that natural or artificial ligands for ICOS potentially suppress HIV-1 replication mainly at the entry stages. | lld:pubmed |
| pubmed-article:15246265 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15246265 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15246265 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15246265 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15246265 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15246265 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15246265 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15246265 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15246265 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15246265 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15246265 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15246265 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15246265 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15246265 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15246265 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15246265 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15246265 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:15246265 | pubmed:issn | 0042-6822 | lld:pubmed |
| pubmed-article:15246265 | pubmed:author | pubmed-author:ZhouXinX | lld:pubmed |
| pubmed-article:15246265 | pubmed:author | pubmed-author:OhashiTakashi... | lld:pubmed |
| pubmed-article:15246265 | pubmed:author | pubmed-author:KannagiMariM | lld:pubmed |
| pubmed-article:15246265 | pubmed:author | pubmed-author:AzumaMiyukiM | lld:pubmed |
| pubmed-article:15246265 | pubmed:author | pubmed-author:MasudaTakaoT | lld:pubmed |
| pubmed-article:15246265 | pubmed:author | pubmed-author:KuboMakotoM | lld:pubmed |
| pubmed-article:15246265 | pubmed:author | pubmed-author:KuriharaKiyos... | lld:pubmed |
| pubmed-article:15246265 | pubmed:author | pubmed-author:NishitsujiHir... | lld:pubmed |
| pubmed-article:15246265 | pubmed:author | pubmed-author:IkedaTamakoT | lld:pubmed |
| pubmed-article:15246265 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15246265 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:15246265 | pubmed:volume | 325 | lld:pubmed |
| pubmed-article:15246265 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15246265 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15246265 | pubmed:pagination | 252-63 | lld:pubmed |
| pubmed-article:15246265 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:15246265 | pubmed:meshHeading | pubmed-meshheading:15246265... | lld:pubmed |
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| pubmed-article:15246265 | pubmed:meshHeading | pubmed-meshheading:15246265... | lld:pubmed |
| pubmed-article:15246265 | pubmed:meshHeading | pubmed-meshheading:15246265... | lld:pubmed |
| pubmed-article:15246265 | pubmed:meshHeading | pubmed-meshheading:15246265... | lld:pubmed |
| pubmed-article:15246265 | pubmed:meshHeading | pubmed-meshheading:15246265... | lld:pubmed |
| pubmed-article:15246265 | pubmed:meshHeading | pubmed-meshheading:15246265... | lld:pubmed |
| pubmed-article:15246265 | pubmed:meshHeading | pubmed-meshheading:15246265... | lld:pubmed |
| pubmed-article:15246265 | pubmed:meshHeading | pubmed-meshheading:15246265... | lld:pubmed |
| pubmed-article:15246265 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15246265 | pubmed:articleTitle | Inducible-costimulator-mediated suppression of human immunodeficiency virus type 1 replication in CD4(+) T lymphocytes. | lld:pubmed |
| pubmed-article:15246265 | pubmed:affiliation | Department of Immunotherapeutics, Graduate School, Tokyo Medical and Dental University, Tokyo 113-8519, Japan. | lld:pubmed |
| pubmed-article:15246265 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15246265 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:15246265 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
