| pubmed-article:15242649 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15242649 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:15242649 | lifeskim:mentions | umls-concept:C0026046 | lld:lifeskim |
| pubmed-article:15242649 | lifeskim:mentions | umls-concept:C1325417 | lld:lifeskim |
| pubmed-article:15242649 | lifeskim:mentions | umls-concept:C0107103 | lld:lifeskim |
| pubmed-article:15242649 | lifeskim:mentions | umls-concept:C0038952 | lld:lifeskim |
| pubmed-article:15242649 | lifeskim:mentions | umls-concept:C1415504 | lld:lifeskim |
| pubmed-article:15242649 | lifeskim:mentions | umls-concept:C1317973 | lld:lifeskim |
| pubmed-article:15242649 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:15242649 | lifeskim:mentions | umls-concept:C0183683 | lld:lifeskim |
| pubmed-article:15242649 | lifeskim:mentions | umls-concept:C0344211 | lld:lifeskim |
| pubmed-article:15242649 | lifeskim:mentions | umls-concept:C1521721 | lld:lifeskim |
| pubmed-article:15242649 | lifeskim:mentions | umls-concept:C1999177 | lld:lifeskim |
| pubmed-article:15242649 | lifeskim:mentions | umls-concept:C1171411 | lld:lifeskim |
| pubmed-article:15242649 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15242649 | pubmed:dateCreated | 2004-7-9 | lld:pubmed |
| pubmed-article:15242649 | pubmed:abstractText | Polyglutamine expansion (polyQ) in the protein huntingtin is pathogenic and responsible for the neuronal toxicity associated with Huntington's disease (HD). Although wild-type huntingtin possesses antiapoptotic properties, the relationship between the neuroprotective functions of huntingtin and pathogenesis of HD remains unclear. Here, we show that huntingtin specifically enhances vesicular transport of brain-derived neurotrophic factor (BDNF) along microtubules. Huntingtin-mediated transport involves huntingtin-associated protein-1 (HAP1) and the p150(Glued) subunit of dynactin, an essential component of molecular motors. BDNF transport is attenuated both in the disease context and by reducing the levels of wild-type huntingtin. The alteration of the huntingtin/HAP1/p150(Glued) complex correlates with reduced association of motor proteins with microtubules. Finally, we find that the polyQ-huntingtin-induced transport deficit results in the loss of neurotrophic support and neuronal toxicity. Our findings indicate that a key role of huntingtin is to promote BDNF transport and suggest that loss of this function might contribute to pathogenesis. | lld:pubmed |
| pubmed-article:15242649 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15242649 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15242649 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15242649 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15242649 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15242649 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15242649 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15242649 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15242649 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15242649 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15242649 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15242649 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:15242649 | pubmed:author | pubmed-author:MacDonaldMarc... | lld:pubmed |
| pubmed-article:15242649 | pubmed:author | pubmed-author:CordelièresFa... | lld:pubmed |
| pubmed-article:15242649 | pubmed:author | pubmed-author:DompierreJim... | lld:pubmed |
| pubmed-article:15242649 | pubmed:author | pubmed-author:HumbertSandri... | lld:pubmed |
| pubmed-article:15242649 | pubmed:author | pubmed-author:SaudouFrédéri... | lld:pubmed |
| pubmed-article:15242649 | pubmed:author | pubmed-author:Borrell-Pagès... | lld:pubmed |
| pubmed-article:15242649 | pubmed:author | pubmed-author:LessmannVolkm... | lld:pubmed |
| pubmed-article:15242649 | pubmed:author | pubmed-author:De MeyJanJ | lld:pubmed |
| pubmed-article:15242649 | pubmed:author | pubmed-author:RangoneHélène... | lld:pubmed |
| pubmed-article:15242649 | pubmed:author | pubmed-author:GauthierLaure... | lld:pubmed |
| pubmed-article:15242649 | pubmed:author | pubmed-author:CharrinBénédi... | lld:pubmed |
| pubmed-article:15242649 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15242649 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:15242649 | pubmed:volume | 118 | lld:pubmed |
| pubmed-article:15242649 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15242649 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15242649 | pubmed:pagination | 127-38 | lld:pubmed |
| pubmed-article:15242649 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:15242649 | pubmed:meshHeading | pubmed-meshheading:15242649... | lld:pubmed |
| pubmed-article:15242649 | pubmed:meshHeading | pubmed-meshheading:15242649... | lld:pubmed |
| pubmed-article:15242649 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15242649 | pubmed:articleTitle | Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules. | lld:pubmed |
| pubmed-article:15242649 | pubmed:affiliation | Unité Mixte de Recherche 146, Centre National de la Recherche Scientifique, Institut Curie, Building 110, Centre Universitaire, 91405 Orsay Cedex, France. | lld:pubmed |
| pubmed-article:15242649 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15242649 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15242649 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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