| pubmed-article:15242554 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15242554 | lifeskim:mentions | umls-concept:C0040053 | lld:lifeskim |
| pubmed-article:15242554 | lifeskim:mentions | umls-concept:C0538674 | lld:lifeskim |
| pubmed-article:15242554 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:15242554 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:15242554 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:15242554 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:15242554 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:15242554 | pubmed:dateCreated | 2004-7-9 | lld:pubmed |
| pubmed-article:15242554 | pubmed:abstractText | Heme oxygenase-1 (HO-1) plays a key role in protecting tissue from oxidative stress. Although some studies implicate HO-1 in modulating thrombosis after vascular injury, the impact of HO-1 on the rate of clot formation in vivo is poorly defined. This study examined the potential function of HO-1 in regulating platelet-dependent arterial thrombosis. Platelet-rich thrombi were induced in C57BL/6J mice by applying 10% ferric chloride to the exposed carotid artery. Mean occlusion time of wild-type mice (n = 10) was 14.6 +/- 1.0 min versus 12.9 +/- 0.6 min for HO-1-/- mice (n = 11, p = 0.17). However, after challenge with hemin, mean occlusion time was significantly longer in wild-type mice (16.3 +/- 1.2 min, n = 15) than HO-1-/- mice (12.0 +/- 1.0 min, n = 9; p = 0.021). Hemin administration induced an approximately twofold increase in oxidative stress, measured as plasma thiobarbituric acid reactive substances. Immunohistochemical analysis revealed that hemin induced a robust increase in HO-1 expression within the carotid arterial wall. Ex vivo blood clotting within a collagen-coated perfusion chamber was studied to determine whether the accelerated thrombosis observed in HO-1-/- mice was contributed to by effects on the blood itself. Under basal conditions, mean clot formation during perfusion of blood over collagen did not differ between wild-type mice and HO-1-/- mice. However, after hemin challenge, mean clot formation was significantly increased in HO-1-/- mice compared with wild-type controls. These results suggest that, under basal conditions, HO-1 does not exert a significant effect on platelet-dependent clot formation in vivo. However, under conditions that stimulate HO-1 production, platelet-dependent thrombus formation is inhibited by HO-1. Enhanced HO-1 expression in response to oxidative stress may represent an adaptive response mechanism to down-regulate platelet activation under prothrombotic conditions. | lld:pubmed |
| pubmed-article:15242554 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15242554 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15242554 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15242554 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15242554 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15242554 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15242554 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15242554 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15242554 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15242554 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15242554 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15242554 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15242554 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15242554 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:15242554 | pubmed:issn | 1523-0864 | lld:pubmed |
| pubmed-article:15242554 | pubmed:author | pubmed-author:FayWilliam... | lld:pubmed |
| pubmed-article:15242554 | pubmed:author | pubmed-author:YetShaw-FangS... | lld:pubmed |
| pubmed-article:15242554 | pubmed:author | pubmed-author:MOREC GCG | lld:pubmed |
| pubmed-article:15242554 | pubmed:author | pubmed-author:MundadaLakshm... | lld:pubmed |
| pubmed-article:15242554 | pubmed:author | pubmed-author:StomelJoshua... | lld:pubmed |
| pubmed-article:15242554 | pubmed:author | pubmed-author:LiuJason JJJ | lld:pubmed |
| pubmed-article:15242554 | pubmed:author | pubmed-author:SunJinhongJ | lld:pubmed |
| pubmed-article:15242554 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15242554 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:15242554 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15242554 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15242554 | pubmed:pagination | 729-35 | lld:pubmed |
| pubmed-article:15242554 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:15242554 | pubmed:meshHeading | pubmed-meshheading:15242554... | lld:pubmed |
| pubmed-article:15242554 | pubmed:meshHeading | pubmed-meshheading:15242554... | lld:pubmed |
| pubmed-article:15242554 | pubmed:meshHeading | pubmed-meshheading:15242554... | lld:pubmed |
| pubmed-article:15242554 | pubmed:meshHeading | pubmed-meshheading:15242554... | lld:pubmed |
| pubmed-article:15242554 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15242554 | pubmed:articleTitle | Induction of heme oxygenase-1 expression inhibits platelet-dependent thrombosis. | lld:pubmed |
| pubmed-article:15242554 | pubmed:publicationType | Letter | lld:pubmed |
| pubmed-article:15242554 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:15242554 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15242554 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:15242554 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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