pubmed-article:15240573 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:15240573 | lifeskim:mentions | umls-concept:C0006675 | lld:lifeskim |
pubmed-article:15240573 | lifeskim:mentions | umls-concept:C0036536 | lld:lifeskim |
pubmed-article:15240573 | lifeskim:mentions | umls-concept:C0014442 | lld:lifeskim |
pubmed-article:15240573 | lifeskim:mentions | umls-concept:C0036537 | lld:lifeskim |
pubmed-article:15240573 | lifeskim:mentions | umls-concept:C0521119 | lld:lifeskim |
pubmed-article:15240573 | lifeskim:mentions | umls-concept:C1979842 | lld:lifeskim |
pubmed-article:15240573 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
pubmed-article:15240573 | lifeskim:mentions | umls-concept:C1551336 | lld:lifeskim |
pubmed-article:15240573 | lifeskim:mentions | umls-concept:C0335218 | lld:lifeskim |
pubmed-article:15240573 | pubmed:issue | 1 | lld:pubmed |
pubmed-article:15240573 | pubmed:dateCreated | 2004-7-8 | lld:pubmed |
pubmed-article:15240573 | pubmed:abstractText | It is generally assumed that the functional consequences of stimulation with Ca2+ -mobilizing agonists are derived exclusively from the second messenger action of intracellular Ca2+, acting on targets inside the cells. However, during Ca2+ signaling events, Ca2+ moves in and out of the cell, causing changes not only in intracellular Ca2+, but also in local extracellular Ca2+. The fact that numerous cell types possess an extracellular Ca2+ "sensor" raises the question of whether these dynamic changes in external [Ca2+] may serve some sort of messenger function. We found that in intact gastric mucosa, the changes in extracellular [Ca2+] secondary to carbachol-induced increases in intracellular [Ca2+] were sufficient and necessary to elicit alkaline secretion and pepsinogen secretion, independent of intracellular [Ca2+] changes. These findings suggest that extracellular Ca2+ can act as a "third messenger" via Ca2+ sensor(s) to regulate specific subsets of tissue function previously assumed to be under the direct control of intracellular Ca2+. | lld:pubmed |
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pubmed-article:15240573 | pubmed:language | eng | lld:pubmed |
pubmed-article:15240573 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:15240573 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:15240573 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:15240573 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:15240573 | pubmed:month | Jul | lld:pubmed |
pubmed-article:15240573 | pubmed:issn | 0021-9525 | lld:pubmed |
pubmed-article:15240573 | pubmed:author | pubmed-author:HoferAldebara... | lld:pubmed |
pubmed-article:15240573 | pubmed:author | pubmed-author:DebellisLucan... | lld:pubmed |
pubmed-article:15240573 | pubmed:author | pubmed-author:ColellaMatild... | lld:pubmed |
pubmed-article:15240573 | pubmed:author | pubmed-author:CaroppoRosaR | lld:pubmed |
pubmed-article:15240573 | pubmed:author | pubmed-author:CurciSilvanaS | lld:pubmed |
pubmed-article:15240573 | pubmed:author | pubmed-author:GerbinoAndrea... | lld:pubmed |
pubmed-article:15240573 | pubmed:author | pubmed-author:FistettoGrego... | lld:pubmed |
pubmed-article:15240573 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:15240573 | pubmed:day | 5 | lld:pubmed |