| pubmed-article:15238082 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15238082 | lifeskim:mentions | umls-concept:C0085243 | lld:lifeskim |
| pubmed-article:15238082 | lifeskim:mentions | umls-concept:C0208355 | lld:lifeskim |
| pubmed-article:15238082 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:15238082 | lifeskim:mentions | umls-concept:C0011847 | lld:lifeskim |
| pubmed-article:15238082 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
| pubmed-article:15238082 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:15238082 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:15238082 | pubmed:dateCreated | 2004-7-7 | lld:pubmed |
| pubmed-article:15238082 | pubmed:abstractText | Inhibition of the 26S proteasome reduces the severity of several immune-mediated diseases. Here, we report that the proteasome also regulates transfer-induced diabetes in nonobese mice. Treatment of recipient mice with the proteasome inhibitor N(alpha)-benzyloxycarbonyl-l-leucyl-l-leucyl-l-leucinal (MG132) resulted in a 76% reduction in transfer-induced diabetes. The closely related inhibitor carbobenzoxy-l-leucyl-l-leucinal that inhibits calpains but not the proteasome had no protective effect, suggesting that MG132 acted via inhibition of the proteasome. MG132 decreased proliferation of transferred T cells in the pancreatic lymph nodes in vivo and prevented their expansion in a dose-dependent manner in vitro, consistent with a direct effect by MG132 on the T cells. MG132 did not prevent migration of transferred T cells into the islets but reduced the number of mice with severe infiltration. We suggest that MG132 prevents transfer-induced diabetes by directly targeting the autoreactive T cells and lowering their diabetogenic potential. | lld:pubmed |
| pubmed-article:15238082 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15238082 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15238082 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15238082 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15238082 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15238082 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15238082 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15238082 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15238082 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15238082 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15238082 | pubmed:issn | 0300-9475 | lld:pubmed |
| pubmed-article:15238082 | pubmed:author | pubmed-author:HallHH | lld:pubmed |
| pubmed-article:15238082 | pubmed:author | pubmed-author:PetrovicJJ | lld:pubmed |
| pubmed-article:15238082 | pubmed:author | pubmed-author:GladMM | lld:pubmed |
| pubmed-article:15238082 | pubmed:author | pubmed-author:POLEE CEC | lld:pubmed |
| pubmed-article:15238082 | pubmed:author | pubmed-author:HöglundPP | lld:pubmed |
| pubmed-article:15238082 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15238082 | pubmed:volume | 60 | lld:pubmed |
| pubmed-article:15238082 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15238082 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15238082 | pubmed:pagination | 134-42 | lld:pubmed |
| pubmed-article:15238082 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:15238082 | pubmed:articleTitle | Inhibition of the proteasome reduces transfer-induced diabetes in nonobese diabetic mice. | lld:pubmed |
| pubmed-article:15238082 | pubmed:affiliation | Microbiology and Tumor Biology Center, Karolinska Institutet, S-171 77 Stockholm, Sweden. | lld:pubmed |
| pubmed-article:15238082 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15238082 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15238082 | lld:pubmed |
