| pubmed-article:15234672 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15234672 | lifeskim:mentions | umls-concept:C0521346 | lld:lifeskim |
| pubmed-article:15234672 | lifeskim:mentions | umls-concept:C0020440 | lld:lifeskim |
| pubmed-article:15234672 | lifeskim:mentions | umls-concept:C0311400 | lld:lifeskim |
| pubmed-article:15234672 | lifeskim:mentions | umls-concept:C1159441 | lld:lifeskim |
| pubmed-article:15234672 | lifeskim:mentions | umls-concept:C1419053 | lld:lifeskim |
| pubmed-article:15234672 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15234672 | pubmed:dateCreated | 2004-7-5 | lld:pubmed |
| pubmed-article:15234672 | pubmed:abstractText | Activation of the platelet-activating factor receptor (PAFR) regulates neural transmission. A PAFR blocker reduced the peak hypoxic (pHVR) but not hypercapnic ventilatory (HCVR) responses in rats [Am. J. Physiol. 275 (1998) R604]. To further examine the role of PAFR in respiratory control, genotype-verified PAFR -/- and PAFR +/+ adult male mice underwent hypoxic and hypercapnic challenges. HCVR was similar in the two groups (p-NS). However, pHVR was significantly reduced in PAFR -/- mice (38 +/- 13% baseline [S.D.]) compared to PAFR +/+ mice (78 +/- 16% baseline; P < 0.001, ANOVA), with reduced tidal volume recruitments during pHVR. In addition, hypoxic ventilatory depression was attenuated in PAFR -/- mice (P < 0.01), and was primarily due to attenuation of the time-dependent decreases in oxygen consumption during sustained hypoxia (P < 0.01). Thus, PAFR expression/function modulates components of the acute ventilatory and metabolic adaptations to hypoxia but not to hypercapnia. Imbalances in PAFR activity may lead to maladaptive regulation of the tightly controlled metabolic-ventilatory relationships during hypoxia. | lld:pubmed |
| pubmed-article:15234672 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15234672 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15234672 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15234672 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15234672 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15234672 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15234672 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15234672 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15234672 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15234672 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15234672 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15234672 | pubmed:issn | 1569-9048 | lld:pubmed |
| pubmed-article:15234672 | pubmed:author | pubmed-author:GozalDavidD | lld:pubmed |
| pubmed-article:15234672 | pubmed:author | pubmed-author:ReevesStephen... | lld:pubmed |
| pubmed-article:15234672 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15234672 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:15234672 | pubmed:volume | 141 | lld:pubmed |
| pubmed-article:15234672 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15234672 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15234672 | pubmed:pagination | 13-20 | lld:pubmed |
| pubmed-article:15234672 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:15234672 | pubmed:meshHeading | pubmed-meshheading:15234672... | lld:pubmed |
| pubmed-article:15234672 | pubmed:meshHeading | pubmed-meshheading:15234672... | lld:pubmed |
| pubmed-article:15234672 | pubmed:meshHeading | pubmed-meshheading:15234672... | lld:pubmed |
| pubmed-article:15234672 | pubmed:meshHeading | pubmed-meshheading:15234672... | lld:pubmed |
| pubmed-article:15234672 | pubmed:meshHeading | pubmed-meshheading:15234672... | lld:pubmed |
| pubmed-article:15234672 | pubmed:meshHeading | pubmed-meshheading:15234672... | lld:pubmed |
| pubmed-article:15234672 | pubmed:meshHeading | pubmed-meshheading:15234672... | lld:pubmed |
| pubmed-article:15234672 | pubmed:meshHeading | pubmed-meshheading:15234672... | lld:pubmed |
| pubmed-article:15234672 | pubmed:meshHeading | pubmed-meshheading:15234672... | lld:pubmed |
| pubmed-article:15234672 | pubmed:meshHeading | pubmed-meshheading:15234672... | lld:pubmed |
| pubmed-article:15234672 | pubmed:meshHeading | pubmed-meshheading:15234672... | lld:pubmed |
| pubmed-article:15234672 | pubmed:meshHeading | pubmed-meshheading:15234672... | lld:pubmed |
| pubmed-article:15234672 | pubmed:meshHeading | pubmed-meshheading:15234672... | lld:pubmed |
| pubmed-article:15234672 | pubmed:meshHeading | pubmed-meshheading:15234672... | lld:pubmed |
| pubmed-article:15234672 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15234672 | pubmed:articleTitle | Platelet-activating factor receptor and respiratory and metabolic responses to hypoxia and hypercapnia. | lld:pubmed |
| pubmed-article:15234672 | pubmed:affiliation | Departments of Pediatrics and Pharmacology and Toxicology, Kosair Children's Hospital Research Institute, University of Louisville School of Medicine, Suite 204, 570 South Preston St., Louisville, KY 40202, USA. | lld:pubmed |
| pubmed-article:15234672 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15234672 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15234672 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15234672 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:19204 | entrezgene:pubmed | pubmed-article:15234672 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15234672 | lld:pubmed |
