| pubmed-article:15232615 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15232615 | lifeskim:mentions | umls-concept:C0029456 | lld:lifeskim |
| pubmed-article:15232615 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:15232615 | lifeskim:mentions | umls-concept:C0029936 | lld:lifeskim |
| pubmed-article:15232615 | lifeskim:mentions | umls-concept:C0332197 | lld:lifeskim |
| pubmed-article:15232615 | lifeskim:mentions | umls-concept:C1419053 | lld:lifeskim |
| pubmed-article:15232615 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15232615 | pubmed:dateCreated | 2004-7-2 | lld:pubmed |
| pubmed-article:15232615 | pubmed:abstractText | While platelet-activating factor (PAF) is produced in various diseases associated with bone resorption, its functions in bone metabolism remain unknown. Using PAF receptor-deficient mice, we evaluated the role of PAF in the development of bone resorption following ovariectomy, a model of postmenopausal osteoporosis. Through observations of bone mineral density and histomorphometric parameters, it was found that bone resorption was markedly attenuated in PAF receptor-deficient mice, indicating that PAF links estrogen depletion and osteoporosis in vivo. Osteoclasts expressed higher amounts of the enzymes required for PAF biosynthesis than osteoblasts. TNF-alpha and IL-1beta increased the acetyl-coenzyme A:lyso-PAF acetyltransferase activity in osteoclasts. Osteoclasts, but not osteoblasts, expressed the functional PAF receptor. PAF receptor stimulation prolonged the survival of osteoclasts in vitro. Furthermore, osteoclasts treated with a PAF receptor antagonist, and also those from PAF receptor-deficient mice, showed reductions in survival rate and Ca resorption activity. Consistently, in organ cultures, bone resorption was significantly suppressed by a PAF receptor antagonist treatment or genetic PAF receptor deficiency. Thus, these results suggest that, through the inflammatory cytokines, estrogen depletion enhances PAF production as a unique autocrine factor for osteoclast functions. Inhibition of PAF function might pave the way for a new strategy to prevent postmenopausal bone loss without disturbing osteoblast functions. | lld:pubmed |
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| pubmed-article:15232615 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15232615 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15232615 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:15232615 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15232615 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15232615 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:15232615 | pubmed:author | pubmed-author:ShimizuTakaoT | lld:pubmed |
| pubmed-article:15232615 | pubmed:author | pubmed-author:IshiiSatoshiS | lld:pubmed |
| pubmed-article:15232615 | pubmed:author | pubmed-author:ShindouHideoH | lld:pubmed |
| pubmed-article:15232615 | pubmed:author | pubmed-author:TakatoTsuyosh... | lld:pubmed |
| pubmed-article:15232615 | pubmed:author | pubmed-author:HikijiHisakoH | lld:pubmed |
| pubmed-article:15232615 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15232615 | pubmed:volume | 114 | lld:pubmed |
| pubmed-article:15232615 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15232615 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15232615 | pubmed:pagination | 85-93 | lld:pubmed |
| pubmed-article:15232615 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:15232615 | pubmed:meshHeading | pubmed-meshheading:15232615... | lld:pubmed |
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| pubmed-article:15232615 | pubmed:meshHeading | pubmed-meshheading:15232615... | lld:pubmed |
| pubmed-article:15232615 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15232615 | pubmed:articleTitle | Absence of platelet-activating factor receptor protects mice from osteoporosis following ovariectomy. | lld:pubmed |
| pubmed-article:15232615 | pubmed:affiliation | Department of Oral and Maxillofacial Surgery, Faculty of Medicine, The University of Tokyo, Bunkyo, Japan. | lld:pubmed |
| pubmed-article:15232615 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15232615 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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