| pubmed-article:15229321 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15229321 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:15229321 | lifeskim:mentions | umls-concept:C0014139 | lld:lifeskim |
| pubmed-article:15229321 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:15229321 | lifeskim:mentions | umls-concept:C1414550 | lld:lifeskim |
| pubmed-article:15229321 | lifeskim:mentions | umls-concept:C1414551 | lld:lifeskim |
| pubmed-article:15229321 | lifeskim:mentions | umls-concept:C1414552 | lld:lifeskim |
| pubmed-article:15229321 | lifeskim:mentions | umls-concept:C1517880 | lld:lifeskim |
| pubmed-article:15229321 | lifeskim:mentions | umls-concept:C1418813 | lld:lifeskim |
| pubmed-article:15229321 | lifeskim:mentions | umls-concept:C0439851 | lld:lifeskim |
| pubmed-article:15229321 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:15229321 | lifeskim:mentions | umls-concept:C1552596 | lld:lifeskim |
| pubmed-article:15229321 | lifeskim:mentions | umls-concept:C1947931 | lld:lifeskim |
| pubmed-article:15229321 | lifeskim:mentions | umls-concept:C1516240 | lld:lifeskim |
| pubmed-article:15229321 | pubmed:issue | 28 | lld:pubmed |
| pubmed-article:15229321 | pubmed:dateCreated | 2004-7-14 | lld:pubmed |
| pubmed-article:15229321 | pubmed:abstractText | FcgammaRI depends for its biological function on both the intracellular domain of the alpha-chain and associated Fc receptor (FcR) gamma-chains. However, functional protein effectors of FcgammaRI's intracellular domain have not been identified. In this study, we identified periplakin (PPL) as a selective interacting protein for the intracellular tail of FcgammaRI but no other activatory FcRs. The interaction was confirmed by coimmunoprecipitation and blot-overlay assays. PPL and FcgammaRI colocalized at the plasma membrane in monocytes and cell transfectants, and both were up-regulated by IFN-gamma. By expressing C-terminal PPL in transfectants, we established a pivotal role for this protein in FcgammaRI ligand binding, endocytosis, and antigen presentation. These data illustrate that intracellular protein interactions with a multisubunit FcR alpha-chain can confer unique properties to the receptor. | lld:pubmed |
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| pubmed-article:15229321 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15229321 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15229321 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:15229321 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15229321 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15229321 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:15229321 | pubmed:author | pubmed-author:van de... | lld:pubmed |
| pubmed-article:15229321 | pubmed:author | pubmed-author:LeusenJeanett... | lld:pubmed |
| pubmed-article:15229321 | pubmed:author | pubmed-author:BeekmanJeffre... | lld:pubmed |
| pubmed-article:15229321 | pubmed:author | pubmed-author:BakemaJantine... | lld:pubmed |
| pubmed-article:15229321 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15229321 | pubmed:day | 13 | lld:pubmed |
| pubmed-article:15229321 | pubmed:volume | 101 | lld:pubmed |
| pubmed-article:15229321 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15229321 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15229321 | pubmed:pagination | 10392-7 | lld:pubmed |
| pubmed-article:15229321 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:15229321 | pubmed:meshHeading | pubmed-meshheading:15229321... | lld:pubmed |
| pubmed-article:15229321 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15229321 | pubmed:articleTitle | Direct interaction between FcgammaRI (CD64) and periplakin controls receptor endocytosis and ligand binding capacity. | lld:pubmed |
| pubmed-article:15229321 | pubmed:affiliation | Immunotherapy Laboratory, Department of Immunology, University Medical Center Utrecht, 3584 EA, Utrecht, The Netherlands. | lld:pubmed |
| pubmed-article:15229321 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15229321 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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