| pubmed-article:15226451 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15226451 | lifeskim:mentions | umls-concept:C1709390 | lld:lifeskim |
| pubmed-article:15226451 | lifeskim:mentions | umls-concept:C1336776 | lld:lifeskim |
| pubmed-article:15226451 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:15226451 | lifeskim:mentions | umls-concept:C1415927 | lld:lifeskim |
| pubmed-article:15226451 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:15226451 | lifeskim:mentions | umls-concept:C0118563 | lld:lifeskim |
| pubmed-article:15226451 | lifeskim:mentions | umls-concept:C1328695 | lld:lifeskim |
| pubmed-article:15226451 | lifeskim:mentions | umls-concept:C0870509 | lld:lifeskim |
| pubmed-article:15226451 | pubmed:issue | 14 | lld:pubmed |
| pubmed-article:15226451 | pubmed:dateCreated | 2004-6-30 | lld:pubmed |
| pubmed-article:15226451 | pubmed:abstractText | Positive cofactor 4 (PC4) is a coactivator that strongly augments transcription by various activators, presumably by facilitating the assembly of the preinitiation complex (PIC). However, our previous observation of stimulation of promoter escape in GAL4-VP16-dependent transcription in the presence of PC4 suggested a possible role for PC4 in this step. Here, we performed quantitative analyses of the stimulatory effects of PC4 on initiation, promoter escape, and elongation in GAL4-VP16-dependent transcription and found that PC4 possesses the ability to stimulate promoter escape in response to GAL4-VP16 in addition to its previously demonstrated effect on PIC assembly. This stimulatory effect of PC4 on promoter escape required TFIIA and the TATA box binding protein-associated factor subunits of TFIID. Furthermore, PC4 displayed physical interactions with both TFIIH and GAL4-VP16 through its coactivator domain, and these interactions were regulated distinctly by PC4 phosphorylation. Finally, GAL4-VP16 and PC4 stimulated both initiation and promoter escape to similar extents on the promoters with three and five GAL4 sites; however, they stimulated promoter escape preferentially on the promoter with a single GAL4 site. These results provide insight into the mechanism by which PC4 permits multiply bound GAL4-VP16 to attain synergy to achieve robust transcriptional activation. | lld:pubmed |
| pubmed-article:15226451 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15226451 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15226451 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15226451 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15226451 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15226451 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15226451 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15226451 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15226451 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15226451 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15226451 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:15226451 | pubmed:author | pubmed-author:FukudaAyaA | lld:pubmed |
| pubmed-article:15226451 | pubmed:author | pubmed-author:NogiYasuhisaY | lld:pubmed |
| pubmed-article:15226451 | pubmed:author | pubmed-author:HisatakeKojiK | lld:pubmed |
| pubmed-article:15226451 | pubmed:author | pubmed-author:MeisterernstM... | lld:pubmed |
| pubmed-article:15226451 | pubmed:author | pubmed-author:TsukuiTohruT | lld:pubmed |
| pubmed-article:15226451 | pubmed:author | pubmed-author:NakadaiTomoyo... | lld:pubmed |
| pubmed-article:15226451 | pubmed:author | pubmed-author:MatsumotoMasa... | lld:pubmed |
| pubmed-article:15226451 | pubmed:author | pubmed-author:ShimadaMihoM | lld:pubmed |
| pubmed-article:15226451 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15226451 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:15226451 | pubmed:owner | NLM | lld:pubmed |
