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pubmed-article:15225652pubmed:abstractTextThe GPX2 gene encodes a homologue of mammalian phospholipid hydroperoxide glutathione peroxidase in Saccharomyces cerevisiae. Previously, we have reported that the oxidative stress-induced expression of GPX2 is strictly regulated by Yap1 and Skn7 transcription factors. Here, we found that the expression of GPX2 is induced by CaCl(2) in a calcineurin (CN)/Crz1-dependent manner, and the CN-dependent response element was specified in the GPX2 promoter. Neither Yap1 nor Skn7 was required for Ca(2+)-dependent induction of GPX2, therefore, distinct regulation for the oxidative stress response and Ca(2+) signal response for GPX2 exists in yeast cells.lld:pubmed
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pubmed-article:15225652pubmed:dateRevised2008-11-21lld:pubmed
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pubmed-article:15225652pubmed:articleTitleDistinct regulatory mechanism of yeast GPX2 encoding phospholipid hydroperoxide glutathione peroxidase by oxidative stress and a calcineurin/Crz1-mediated Ca2+ signaling pathway.lld:pubmed
pubmed-article:15225652pubmed:affiliationLaboratory of Molecular Microbiology, Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Uji, Kyoto 611-0011, Japan.lld:pubmed
pubmed-article:15225652pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15225652pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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