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pubmed-article:15215127pubmed:abstractTextAntiviral agents are urgently needed to fight severe acute respiratory syndrome (SARS). We showed that niclosamide, an existing antihelminthic drug, was able to inhibit replication of a newly discovered coronavirus, SARS-CoV; viral antigen synthesis was totally abolished at a niclosamide concentration of 1.56 microM, as revealed by immunoblot analysis. Thus, niclosamide represents a promising drug candidate for the effective treatment of SARS-CoV infection.lld:pubmed
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pubmed-article:15215127pubmed:articleTitleInhibition of severe acute respiratory syndrome coronavirus replication by niclosamide.lld:pubmed
pubmed-article:15215127pubmed:affiliationInstitute of Preventive Medicine, National Defense Medical College, National Defense University, Taipei, Taiwan.lld:pubmed
pubmed-article:15215127pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15215127pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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