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pubmed-article:15213383pubmed:abstractTextRecently, the multivariate complex normal distribution has been used to develop a maximum-likelihood probability function for single-wavelength anomalous diffraction phasing and refinement of heavy-atom parameters [Pannu & Read (2004), Acta Cryst. D60, 22-27]. The function accounts explicitly for the correlations between the observed and calculated Friedel mates and their errors. However, the method of derivation of the equation described by Pannu & Read (2004) leads to a complicated likelihood expression that suffers from a number of algorithmic limitations. Here, an alternative derivation of the P(SAD) function is described that leads to simplified algorithmic requirements and that allows an intuitive understanding of the expression.lld:pubmed
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pubmed-article:15213383pubmed:authorpubmed-author:McCoyAirlie...lld:pubmed
pubmed-article:15213383pubmed:authorpubmed-author:StoroniLauren...lld:pubmed
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pubmed-article:15213383pubmed:pagination1220-8lld:pubmed
pubmed-article:15213383pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:15213383pubmed:year2004lld:pubmed
pubmed-article:15213383pubmed:articleTitleSimple algorithm for a maximum-likelihood SAD function.lld:pubmed
pubmed-article:15213383pubmed:affiliationUniversity of Cambridge, Department of Haematology, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Hills Road, Cambridge CB2 2XY, England.lld:pubmed
pubmed-article:15213383pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15213383pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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