Linked Life Data

15208625

Source:http://linkedlifedata.com/resource/pubmed/id/15208625

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:15208625rdf:typepubmed:Citationlld:pubmed
pubmed-article:15208625lifeskim:mentionsumls-concept:C1708726lld:lifeskim
pubmed-article:15208625lifeskim:mentionsumls-concept:C1366876lld:lifeskim
pubmed-article:15208625lifeskim:mentionsumls-concept:C1833235lld:lifeskim
pubmed-article:15208625lifeskim:mentionsumls-concept:C1704259lld:lifeskim
pubmed-article:15208625lifeskim:mentionsumls-concept:C0439855lld:lifeskim
pubmed-article:15208625lifeskim:mentionsumls-concept:C1705987lld:lifeskim
pubmed-article:15208625lifeskim:mentionsumls-concept:C1521840lld:lifeskim
pubmed-article:15208625pubmed:issue7lld:pubmed
pubmed-article:15208625pubmed:dateCreated2004-6-30lld:pubmed
pubmed-article:15208625pubmed:abstractTextDuring skeletal myogenesis, genomic reprogramming toward terminal differentiation is achieved by recruiting chromatin-modifying enzymes to muscle-specific loci. The relative contribution of extracellular signaling cascades in targeting these enzymes to individual genes is unknown. Here we show that the differentiation-activated p38 pathway targets the SWI-SNF chromatin-remodeling complex to myogenic loci. Upon differentiation, p38 kinases were recruited to the chromatin of muscle-regulatory elements. Blockade of p38 alpha/beta repressed the transcription of muscle genes by preventing recruitment of the SWI-SNF complex at these elements without affecting chromatin binding of muscle-regulatory factors and acetyltransferases. The SWI-SNF subunit BAF60 could be phosphorylated by p38 alpha-beta in vitro, and forced activation of p38 alpha/beta in myoblasts by expression of a constitutively active MKK6 (refs. 5,6,7) promoted unscheduled SWI-SNF recruitment to the myogenin promoter. Conversely, inactivation of SWI-SNF enzymatic subunits abrogated MKK6-dependent induction of muscle gene expression. These results identify an unexpected function of differentiation-activated p38 in converting external cues into chromatin modifications at discrete loci, by selectively targeting SWI-SNF to muscle-regulatory elements.lld:pubmed
pubmed-article:15208625pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15208625pubmed:languageenglld:pubmed
pubmed-article:15208625pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15208625pubmed:citationSubsetIMlld:pubmed
pubmed-article:15208625pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15208625pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15208625pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15208625pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15208625pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15208625pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15208625pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15208625pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15208625pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:15208625pubmed:statusMEDLINElld:pubmed
pubmed-article:15208625pubmed:monthJullld:pubmed
pubmed-article:15208625pubmed:issn1061-4036lld:pubmed
pubmed-article:15208625pubmed:authorpubmed-author:HillDavid ADAlld:pubmed
pubmed-article:15208625pubmed:authorpubmed-author:ImbalzanoAnth...lld:pubmed
pubmed-article:15208625pubmed:authorpubmed-author:PuriPier...lld:pubmed
pubmed-article:15208625pubmed:authorpubmed-author:SimoneCristia...lld:pubmed
pubmed-article:15208625pubmed:authorpubmed-author:LatellaLuciaLlld:pubmed
pubmed-article:15208625pubmed:authorpubmed-author:ForcalesSonia...lld:pubmed
pubmed-article:15208625pubmed:issnTypePrintlld:pubmed
pubmed-article:15208625pubmed:volume36lld:pubmed
pubmed-article:15208625pubmed:ownerNLMlld:pubmed
pubmed-article:15208625pubmed:authorsCompleteYlld:pubmed
pubmed-article:15208625pubmed:pagination738-43lld:pubmed
pubmed-article:15208625pubmed:dateRevised2009-11-19lld:pubmed
pubmed-article:15208625pubmed:meshHeadingpubmed-meshheading:15208625...lld:pubmed
pubmed-article:15208625pubmed:meshHeadingpubmed-meshheading:15208625...lld:pubmed
pubmed-article:15208625pubmed:meshHeadingpubmed-meshheading:15208625...lld:pubmed
pubmed-article:15208625pubmed:meshHeadingpubmed-meshheading:15208625...lld:pubmed
pubmed-article:15208625pubmed:meshHeadingpubmed-meshheading:15208625...lld:pubmed
pubmed-article:15208625pubmed:meshHeadingpubmed-meshheading:15208625...lld:pubmed
pubmed-article:15208625pubmed:meshHeadingpubmed-meshheading:15208625...lld:pubmed
pubmed-article:15208625pubmed:meshHeadingpubmed-meshheading:15208625...lld:pubmed
pubmed-article:15208625pubmed:meshHeadingpubmed-meshheading:15208625...lld:pubmed
pubmed-article:15208625pubmed:year2004lld:pubmed
pubmed-article:15208625pubmed:articleTitlep38 pathway targets SWI-SNF chromatin-remodeling complex to muscle-specific loci.lld:pubmed
pubmed-article:15208625pubmed:affiliationLaboratory of Gene Expression, Dulbecco Telethon Institute at Fondazione A. Cesalpino, Institute of Cell Biology and Tissue Engineering, San Raffaele Biomedical Science Park of Rome, Rome 00128, Italy.lld:pubmed
pubmed-article:15208625pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15208625pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:15208625lld:pubmed
More...