| pubmed-article:15207710 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15207710 | lifeskim:mentions | umls-concept:C0076380 | lld:lifeskim |
| pubmed-article:15207710 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:15207710 | lifeskim:mentions | umls-concept:C0815279 | lld:lifeskim |
| pubmed-article:15207710 | lifeskim:mentions | umls-concept:C0441843 | lld:lifeskim |
| pubmed-article:15207710 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15207710 | pubmed:dateCreated | 2004-6-21 | lld:pubmed |
| pubmed-article:15207710 | pubmed:abstractText | We investigated the molecular mechanism underlying the neuroprotective effect of theanine, a green tea component, using primary cultured rat cortical neurons, focusing on group I metabotropic glutamate receptors (mGluRs). Theanine and a group I mGluR agonist, DHPG, inhibited the delayed death of neurons caused by brief exposure to glutamate, and this effect of theanine was abolished by group I mGluR antagonists. Although the administration of glutamate alone decreased the neuronal expression of phospholipase C (PLC)-beta1 and -gamma1, which are linked to group I mGluRs, their expression was equal to the control levels on cotreatment with theanine. Treatment with theanine or DHPG alone for 5-7 days resulted in increased expression of PLC-beta1 and -gamma1, and the action of theanine was completely abolished by group I mGluR antagonists. These findings indicate that group I mGluRs might be involved in neuroprotective effect of theanine by increasing the expression levels of PLC-beta1 and -gamma1. | lld:pubmed |
| pubmed-article:15207710 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15207710 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15207710 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15207710 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15207710 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15207710 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15207710 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15207710 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15207710 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15207710 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15207710 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15207710 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15207710 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15207710 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15207710 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15207710 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15207710 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15207710 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:15207710 | pubmed:author | pubmed-author:ShimohamaShun... | lld:pubmed |
| pubmed-article:15207710 | pubmed:author | pubmed-author:AokiHiromitsu... | lld:pubmed |
| pubmed-article:15207710 | pubmed:author | pubmed-author:NagaiKatsuhit... | lld:pubmed |
| pubmed-article:15207710 | pubmed:author | pubmed-author:NagasawaKazuk... | lld:pubmed |
| pubmed-article:15207710 | pubmed:author | pubmed-author:FujimotoSadak... | lld:pubmed |
| pubmed-article:15207710 | pubmed:author | pubmed-author:YasudaEriE | lld:pubmed |
| pubmed-article:15207710 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15207710 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:15207710 | pubmed:volume | 320 | lld:pubmed |
| pubmed-article:15207710 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15207710 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15207710 | pubmed:pagination | 116-22 | lld:pubmed |
| pubmed-article:15207710 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:15207710 | pubmed:meshHeading | pubmed-meshheading:15207710... | lld:pubmed |
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| pubmed-article:15207710 | pubmed:meshHeading | pubmed-meshheading:15207710... | lld:pubmed |
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| pubmed-article:15207710 | pubmed:meshHeading | pubmed-meshheading:15207710... | lld:pubmed |
| pubmed-article:15207710 | pubmed:meshHeading | pubmed-meshheading:15207710... | lld:pubmed |
| pubmed-article:15207710 | pubmed:meshHeading | pubmed-meshheading:15207710... | lld:pubmed |
| pubmed-article:15207710 | pubmed:meshHeading | pubmed-meshheading:15207710... | lld:pubmed |
| pubmed-article:15207710 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15207710 | pubmed:articleTitle | Possible involvement of group I mGluRs in neuroprotective effect of theanine. | lld:pubmed |
| pubmed-article:15207710 | pubmed:affiliation | Department of Environmental Biochemistry, Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan. nagasawa@mb.kyoto-phu.ac.jp | lld:pubmed |
| pubmed-article:15207710 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15207710 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
