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pubmed-article:15201636pubmed:abstractTextAssessment of high-risk drinking in the general population can be problematic: questionnaire-based instruments may carry the problem of random or systematic recall bias, and the effectiveness of screening of single biomarkers has been shown to be insufficient. In this article, we analyze the alcohol intake/biomarker relationship of carbohydrate-deficient transferrin (CDT), gamma-glutamyltransferase (GGT), and erythrocyte mean corpuscular volume (MCV). Specific aims were (1) screening effectiveness comparison of GGT, CDT, and MCV in terms of sensitivity, specificity, and positive (PPVs) and negative predictive values (NPVs) and the effect of covariates on these measures; (2) the comparison of summary measures for the effectiveness of screening: the receiver characteristic curve (ROC) and the area under the ROC; and (3) to answer the question of which covariates effect which biomarkers and whether accounting for relevant covariates increases the prognostic value of biomarkers to levels that allow for application in the general population.lld:pubmed
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pubmed-article:15201636pubmed:authorpubmed-author:JohnUlrichUlld:pubmed
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pubmed-article:15201636pubmed:authorpubmed-author:AlteDietrichDlld:pubmed
pubmed-article:15201636pubmed:copyrightInfoCopyright 2004 Research Society on Alcoholismlld:pubmed
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pubmed-article:15201636pubmed:volume28lld:pubmed
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pubmed-article:15201636pubmed:articleTitleLaboratory markers carbohydrate-deficient transferrin, gamma-glutamyltransferase, and mean corpuscular volume are not useful as screening tools for high-risk drinking in the general population: results from the Study of Health in Pomerania (SHIP).lld:pubmed
pubmed-article:15201636pubmed:affiliationErnst-Moritz-Arndt-Universität Greifswald, Institut für Epidemiologie und Sozialmedizin (Institute of Epidemiology and Social Medicine), Greifswald, Germany. alte@uni-greifswald.delld:pubmed
pubmed-article:15201636pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15201636pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:15201636pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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