| pubmed-article:15197790 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15197790 | lifeskim:mentions | umls-concept:C0012634 | lld:lifeskim |
| pubmed-article:15197790 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:15197790 | lifeskim:mentions | umls-concept:C0205282 | lld:lifeskim |
| pubmed-article:15197790 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:15197790 | pubmed:dateCreated | 2004-6-15 | lld:pubmed |
| pubmed-article:15197790 | pubmed:abstractText | Tumor endothelium represents a valuable target for cancer therapy. The vasculature plays a critical role in the survival and continued growth of solid tumor masses; in addition, the inherent differences between tumor blood vessels and blood vessels associated with normal tissue make the tumor vasculature a unique target on which to base the design of novel therapeutics, which may allow highly selective treatment of malignant disease. Therapeutic strategies that target and disrupt the already formed vessel networks of growing tumors are actively being pursued. The goal of these approaches is to induce a rapid and catastrophic shutdown of the vascular function of the tumor so that blood flow is arrested and tumor cell death due to the resulting oxygen and nutrient deprivation and buildup of waste products occurs. | lld:pubmed |
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| pubmed-article:15197790 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15197790 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15197790 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:15197790 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15197790 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15197790 | pubmed:issn | 0008-543X | lld:pubmed |
| pubmed-article:15197790 | pubmed:author | pubmed-author:SiemannDietma... | lld:pubmed |
| pubmed-article:15197790 | pubmed:author | pubmed-author:HorsmanMichae... | lld:pubmed |
| pubmed-article:15197790 | pubmed:author | pubmed-author:ChaplinDavid... | lld:pubmed |
| pubmed-article:15197790 | pubmed:copyrightInfo | Copyright 2004 American Cancer Society. | lld:pubmed |
| pubmed-article:15197790 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15197790 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:15197790 | pubmed:volume | 100 | lld:pubmed |
| pubmed-article:15197790 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15197790 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15197790 | pubmed:pagination | 2491-9 | lld:pubmed |
| pubmed-article:15197790 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:15197790 | pubmed:meshHeading | pubmed-meshheading:15197790... | lld:pubmed |
| pubmed-article:15197790 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15197790 | pubmed:articleTitle | Vascular-targeting therapies for treatment of malignant disease. | lld:pubmed |
| pubmed-article:15197790 | pubmed:affiliation | Department of Radiation Oncology, University of Florida, Gainesville, Florida 32610, USA. siemadw@ufl.edu | lld:pubmed |
| pubmed-article:15197790 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15197790 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15197790 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:15197790 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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