The methods for handling missing data in clinical trials influence sample size requirements.

Source:http://linkedlifedata.com/resource/pubmed/id/15196614

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Authors

Giraudeau B, Dougados M, Maillefert JF, Ravaud P, Auleley GR, Baron G

Affiliation

Université Paris V-René Descartes, Faculté de Médecine Cochin Port-Royal and Clinique de Rhumatologie, Hôpital Cochin, AP-HP, Paris, France.

Abstract

Results of studies estimating osteoarthritis progression may be affected by missing values. In clinical trials assessing disease-modifying osteoarthritis drugs, sample sizes should be calculated using close estimates of outcome variables.

PMID
15196614