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pubmed-article:15196002pubmed:abstractTextRecently, it has been demonstrated that family 2 cystatins upregulate interleukin-6 production by human gingival fibroblasts. In the present study, we investigated the effects of cystatin SA on cytokine production by helper T cells. Human CD4-positive T cells were cultured with phytohemagglutinin in the presence or absence of 0.1 microM recombinant cystatin SA1 or SA2. When the amounts of interleukin-4 (IL-4) and interferon-gamma (IFNgamma) were analyzed in an ELISA system after stimulation with either cystatin, no significantly increased levels of IL-4 were detected. However, the amounts of IFNgamma were significantly increased after stimulation with the cystatins. Our results suggest that salivary family 2 cystatins are involved in immune responses through the cytokine network.lld:pubmed
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pubmed-article:15196002pubmed:authorpubmed-author:ItoTaichiTlld:pubmed
pubmed-article:15196002pubmed:authorpubmed-author:KatoTetsuoTlld:pubmed
pubmed-article:15196002pubmed:authorpubmed-author:MinaguchiKiyo...lld:pubmed
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pubmed-article:15196002pubmed:volume385lld:pubmed
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pubmed-article:15196002pubmed:pagination419-22lld:pubmed
pubmed-article:15196002pubmed:dateRevised2008-11-21lld:pubmed
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pubmed-article:15196002pubmed:year2004lld:pubmed
pubmed-article:15196002pubmed:articleTitleCystatin SA, a cysteine proteinase inhibitor, induces interferon-gamma expression in CD4-positive T cells.lld:pubmed
pubmed-article:15196002pubmed:affiliationOral Health Science Center, Department of Microbiology, Tokyo Dental College, 1-2-2 Masago, Mihama-ku, Chiba 261-8502, Japan. tekato@tdc.ac.jplld:pubmed
pubmed-article:15196002pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:15196002pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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