| pubmed-article:15188273 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15188273 | lifeskim:mentions | umls-concept:C0008051 | lld:lifeskim |
| pubmed-article:15188273 | lifeskim:mentions | umls-concept:C0022889 | lld:lifeskim |
| pubmed-article:15188273 | lifeskim:mentions | umls-concept:C0596290 | lld:lifeskim |
| pubmed-article:15188273 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:15188273 | lifeskim:mentions | umls-concept:C1707520 | lld:lifeskim |
| pubmed-article:15188273 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:15188273 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:15188273 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:15188273 | pubmed:dateCreated | 2004-6-9 | lld:pubmed |
| pubmed-article:15188273 | pubmed:abstractText | In vertebrates, the paired-box transcription factor Pax-2 is one of the earliest markers of the developing inner ear and is robustly expressed in the otic placode and the otic vesicle. Mutations in the Pax-2 gene result in developmental defects of the vestibular and auditory apparatus. We set out to investigate whether regions of Pax-2 expression in the developing otic vesicle correlate with areas of cell proliferation or cell death, which would indicate a possible role of Pax-2 in these processes. Regionalized proliferation and local apoptosis are the principal mechanisms that lead to the complex morphogenesis of the highly compartmentalized inner ear starting from a simple vesicle. We found a high correlation of Pax-2 expression with proliferating cells in the walls of the early otic vesicle. Apoptotic cells were mostly localized outside of the Pax-2-expressing regions. At later stages, we found the highest intensity of proliferating and Pax-2-positive cells in areas of the developing sensory epithelia. When hair cells begin to differentiate, they maintain a lower level of Pax-2 expression than neighboring cells for a brief period, before they completely down-regulate expression of this transcription factor. We conclude that a significant proportion of proliferating cells in the developing otocyst express Pax-2, in particular in regions that include developing sensory patches. This implicates Pax-2 as a marker for proliferating hair and supporting cell progenitors. Furthermore, the likelihood that Pax-2-expressing cells in the otocyst die by apoptosis is much lower when compared with cells residing in Pax-2-negative regions. | lld:pubmed |
| pubmed-article:15188273 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15188273 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15188273 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15188273 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15188273 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15188273 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15188273 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15188273 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15188273 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15188273 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:15188273 | pubmed:issn | 0022-3034 | lld:pubmed |
| pubmed-article:15188273 | pubmed:author | pubmed-author:HongLiuL | lld:pubmed |
| pubmed-article:15188273 | pubmed:author | pubmed-author:HellerStefanS | lld:pubmed |
| pubmed-article:15188273 | pubmed:author | pubmed-author:MutaiHidekiH | lld:pubmed |
| pubmed-article:15188273 | pubmed:author | pubmed-author:LiHuaweiH | lld:pubmed |
| pubmed-article:15188273 | pubmed:author | pubmed-author:CorralesC... | lld:pubmed |
| pubmed-article:15188273 | pubmed:copyrightInfo | Copyright 2004 Wiley Periodicals, Inc. J Neurobiol 60: 61-70, 2004 | lld:pubmed |
| pubmed-article:15188273 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15188273 | pubmed:volume | 60 | lld:pubmed |
| pubmed-article:15188273 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15188273 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15188273 | pubmed:pagination | 61-70 | lld:pubmed |
| pubmed-article:15188273 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:15188273 | pubmed:meshHeading | pubmed-meshheading:15188273... | lld:pubmed |
| pubmed-article:15188273 | pubmed:meshHeading | pubmed-meshheading:15188273... | lld:pubmed |
| pubmed-article:15188273 | pubmed:meshHeading | pubmed-meshheading:15188273... | lld:pubmed |
| pubmed-article:15188273 | pubmed:meshHeading | pubmed-meshheading:15188273... | lld:pubmed |
| pubmed-article:15188273 | pubmed:meshHeading | pubmed-meshheading:15188273... | lld:pubmed |
| pubmed-article:15188273 | pubmed:meshHeading | pubmed-meshheading:15188273... | lld:pubmed |
| pubmed-article:15188273 | pubmed:meshHeading | pubmed-meshheading:15188273... | lld:pubmed |
| pubmed-article:15188273 | pubmed:meshHeading | pubmed-meshheading:15188273... | lld:pubmed |
| pubmed-article:15188273 | pubmed:meshHeading | pubmed-meshheading:15188273... | lld:pubmed |
| pubmed-article:15188273 | pubmed:meshHeading | pubmed-meshheading:15188273... | lld:pubmed |
| pubmed-article:15188273 | pubmed:meshHeading | pubmed-meshheading:15188273... | lld:pubmed |
| pubmed-article:15188273 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15188273 | pubmed:articleTitle | Correlation of Pax-2 expression with cell proliferation in the developing chicken inner ear. | lld:pubmed |
| pubmed-article:15188273 | pubmed:affiliation | Department of Otolaryngology and Program in Neuroscience, Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, 02114, USA. | lld:pubmed |
| pubmed-article:15188273 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15188273 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15188273 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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