| pubmed-article:15187121 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15187121 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:15187121 | lifeskim:mentions | umls-concept:C1517735 | lld:lifeskim |
| pubmed-article:15187121 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:15187121 | lifeskim:mentions | umls-concept:C1824668 | lld:lifeskim |
| pubmed-article:15187121 | lifeskim:mentions | umls-concept:C1817919 | lld:lifeskim |
| pubmed-article:15187121 | lifeskim:mentions | umls-concept:C1306673 | lld:lifeskim |
| pubmed-article:15187121 | lifeskim:mentions | umls-concept:C0439661 | lld:lifeskim |
| pubmed-article:15187121 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:15187121 | pubmed:dateCreated | 2004-6-9 | lld:pubmed |
| pubmed-article:15187121 | pubmed:abstractText | Studies on human B cells have featured CD27 as a marker and mediator of the B cell response. We have studied CD27 expression and function on B cells in the mouse. We find that B cells acquire CD27 at the centroblast stage and lose it progressively upon further differentiation. It is not a marker for somatically mutated B cells and is present at very low frequency on memory B cells. Enrichment of CD27 among centroblasts and the presence of its ligand CD70 on occasional T and B cells in or near germinal centers (GCs) suggested a role for CD27/CD70 interactions in clonal B cell expansion. Accordingly, GC formation in response to influenza virus infection was delayed in CD27 knockout mice. CD27 deficiency did not affect somatic hypermutation or serum levels of virus-specific IgM, IgG, and IgA attained in primary and recall responses. Adoptive transfer of T and B cells into CD27/CD28(-/-) mice revealed that CD27 promotes GC formation and consequent IgG production by two distinct mechanisms. Stimulation of CD27 on B cells by CD28(+) Th cells accelerates GC formation, most likely by promoting centroblast expansion. In addition, CD27 on T cells can partially substitute for CD28 in supporting GC formation. | lld:pubmed |
| pubmed-article:15187121 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15187121 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15187121 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:15187121 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15187121 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15187121 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15187121 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15187121 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:15187121 | pubmed:author | pubmed-author:BorstJannieJ | lld:pubmed |
| pubmed-article:15187121 | pubmed:author | pubmed-author:JacobsHeinzH | lld:pubmed |
| pubmed-article:15187121 | pubmed:author | pubmed-author:XiaoYanlingY | lld:pubmed |
| pubmed-article:15187121 | pubmed:author | pubmed-author:HendriksJenny... | lld:pubmed |
| pubmed-article:15187121 | pubmed:author | pubmed-author:LangerakPetra... | lld:pubmed |
| pubmed-article:15187121 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15187121 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:15187121 | pubmed:volume | 172 | lld:pubmed |
| pubmed-article:15187121 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15187121 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15187121 | pubmed:pagination | 7432-41 | lld:pubmed |
| pubmed-article:15187121 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:15187121 | pubmed:meshHeading | pubmed-meshheading:15187121... | lld:pubmed |
| pubmed-article:15187121 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15187121 | pubmed:articleTitle | CD27 is acquired by primed B cells at the centroblast stage and promotes germinal center formation. | lld:pubmed |
| pubmed-article:15187121 | pubmed:affiliation | Division of Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands. | lld:pubmed |
| pubmed-article:15187121 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15187121 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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