| pubmed-article:15182736 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15182736 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:15182736 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:15182736 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:15182736 | lifeskim:mentions | umls-concept:C0036037 | lld:lifeskim |
| pubmed-article:15182736 | lifeskim:mentions | umls-concept:C0205095 | lld:lifeskim |
| pubmed-article:15182736 | lifeskim:mentions | umls-concept:C0001443 | lld:lifeskim |
| pubmed-article:15182736 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:15182736 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:15182736 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:15182736 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:15182736 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:15182736 | pubmed:dateCreated | 2004-6-8 | lld:pubmed |
| pubmed-article:15182736 | pubmed:abstractText | The modulatory effect of adenosine on gamma-aminobutyric acid (GABA)-activated whole-cell currents were investigated in the neurons acutely dissociated from the rat sacral dorsal commissural nucleus (SDCN) using the nystatin perforated patch recording configuration under the voltage-clamp conditions. The results showed that: (1) GABA acted on GABAA receptor and elicited inward Cl- currents (IGABA) at a holding potential (VH) of -40 mV; (2) adenosine suppressed GABA-induced Cl- current without affecting the reversal potential of IGABA and the apparent affinity of GABA to its receptor; (3) N6-cyclohexyladenosine mimicked the suppression effect of adenosine on IGABA, whereas 8-cyclopentyl-1,3-dipropylxanthine blocked the suppression effect of adenosine; (4) adenosine fails to suppress IGABA on the neurons that were pretreated with bisindolylmaleimide I (BIM), while after pretreatment with H-89, the inhibitory effect of adenosine on IGABA were not affected; (5) the suppression effect of adenosine on IGABA remained in the presence of BAPTA-AM. The present results indicate that the suppression of adenosine on IGABA is mediated by adenosine A1 receptor and through a Ca2+-independent protein kinase C transduction pathway, and that the interactions between adenosine and GABA might participate in the modulation of nociceptive information transmission at the SDCN. | lld:pubmed |
| pubmed-article:15182736 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15182736 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15182736 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15182736 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15182736 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15182736 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15182736 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15182736 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15182736 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15182736 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15182736 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:15182736 | pubmed:issn | 1566-0702 | lld:pubmed |
| pubmed-article:15182736 | pubmed:author | pubmed-author:FoàVV | lld:pubmed |
| pubmed-article:15182736 | pubmed:author | pubmed-author:JiaL YLY | lld:pubmed |
| pubmed-article:15182736 | pubmed:author | pubmed-author:LiYun-QingYQ | lld:pubmed |
| pubmed-article:15182736 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15182736 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:15182736 | pubmed:volume | 111 | lld:pubmed |
| pubmed-article:15182736 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15182736 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15182736 | pubmed:pagination | 71-9 | lld:pubmed |
| pubmed-article:15182736 | pubmed:dateRevised | 2009-8-12 | lld:pubmed |
| pubmed-article:15182736 | pubmed:meshHeading | pubmed-meshheading:15182736... | lld:pubmed |
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| pubmed-article:15182736 | pubmed:meshHeading | pubmed-meshheading:15182736... | lld:pubmed |
| pubmed-article:15182736 | pubmed:meshHeading | pubmed-meshheading:15182736... | lld:pubmed |
| pubmed-article:15182736 | pubmed:meshHeading | pubmed-meshheading:15182736... | lld:pubmed |
| pubmed-article:15182736 | pubmed:meshHeading | pubmed-meshheading:15182736... | lld:pubmed |
| pubmed-article:15182736 | pubmed:meshHeading | pubmed-meshheading:15182736... | lld:pubmed |
| pubmed-article:15182736 | pubmed:meshHeading | pubmed-meshheading:15182736... | lld:pubmed |
| pubmed-article:15182736 | pubmed:meshHeading | pubmed-meshheading:15182736... | lld:pubmed |
| pubmed-article:15182736 | pubmed:meshHeading | pubmed-meshheading:15182736... | lld:pubmed |
| pubmed-article:15182736 | pubmed:meshHeading | pubmed-meshheading:15182736... | lld:pubmed |
| pubmed-article:15182736 | pubmed:meshHeading | pubmed-meshheading:15182736... | lld:pubmed |
| pubmed-article:15182736 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15182736 | pubmed:articleTitle | Adenosine suppresses GABAA receptor-mediated responses in rat sacral dorsal commissural neurons. | lld:pubmed |
| pubmed-article:15182736 | pubmed:affiliation | Department of Anatomy and K.K. Leung Brain Research Centre, The Fourth Military Medical University, No. 17, W. Chang-le Road, Xi'an 710032, PR China. | lld:pubmed |
| pubmed-article:15182736 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15182736 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15182736 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:15182736 | lld:pubmed |
