| pubmed-article:15180962 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15180962 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:15180962 | lifeskim:mentions | umls-concept:C0031715 | lld:lifeskim |
| pubmed-article:15180962 | lifeskim:mentions | umls-concept:C0070876 | lld:lifeskim |
| pubmed-article:15180962 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:15180962 | lifeskim:mentions | umls-concept:C1335676 | lld:lifeskim |
| pubmed-article:15180962 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:15180962 | pubmed:dateCreated | 2004-7-30 | lld:pubmed |
| pubmed-article:15180962 | pubmed:abstractText | Many cardiovascular disease states end in progressive heart failure. Changes in intracellular calcium handling, including a reduced activity of the sarcoplasmic reticulum calcium pump (SERCA), contribute to this contractile dysfunction. As the regulatory protein phospholamban can inhibit the calcium pump, we evaluated it as a potential target to improve cardiac function. In this study, we describe a recombinant antibody-based protein (PLN-Ab) that binds to the cytoplasmic domain of phospholamban. Fluorescence resonance energy transfer (FRET) studies suggest that PLN-Ab mimics the effects of phospholamban phosphorylation. PLN-Ab accelerated the decay of the calcium transient when expressed in neonatal rat and adult mouse ventricular cardiac myocytes. In addition, direct injection of adenovirus encoding PLN-Ab into the diabetic mouse heart enhanced contractility when measured in vivo by echocardiography and in ex vivo Langendorff perfused hearts. The PLN-Ab provides a novel therapeutic approach to improving contractility through in vivo expression of an antibody inside cardiac myocytes. | lld:pubmed |
| pubmed-article:15180962 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15180962 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15180962 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15180962 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15180962 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15180962 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15180962 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15180962 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15180962 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15180962 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15180962 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15180962 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15180962 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15180962 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15180962 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15180962 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15180962 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15180962 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15180962 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15180962 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:15180962 | pubmed:issn | 1530-6860 | lld:pubmed |
| pubmed-article:15180962 | pubmed:author | pubmed-author:DillmannWolfg... | lld:pubmed |
| pubmed-article:15180962 | pubmed:author | pubmed-author:BelkeDarrell... | lld:pubmed |
| pubmed-article:15180962 | pubmed:author | pubmed-author:SwansonEricE | lld:pubmed |
| pubmed-article:15180962 | pubmed:author | pubmed-author:SilvermanGreg... | lld:pubmed |
| pubmed-article:15180962 | pubmed:author | pubmed-author:TrostSusanne... | lld:pubmed |
| pubmed-article:15180962 | pubmed:author | pubmed-author:BluhmWolfgang... | lld:pubmed |
| pubmed-article:15180962 | pubmed:author | pubmed-author:MeyerMarkusM | lld:pubmed |
| pubmed-article:15180962 | pubmed:author | pubmed-author:ScottBrianB | lld:pubmed |
| pubmed-article:15180962 | pubmed:author | pubmed-author:HoPeterP | lld:pubmed |
| pubmed-article:15180962 | pubmed:author | pubmed-author:DieterleThoma... | lld:pubmed |
| pubmed-article:15180962 | pubmed:author | pubmed-author:McDonoughPatr... | lld:pubmed |
| pubmed-article:15180962 | pubmed:author | pubmed-author:CaryStephen... | lld:pubmed |
| pubmed-article:15180962 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:15180962 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:15180962 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15180962 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15180962 | pubmed:pagination | 1312-4 | lld:pubmed |
| pubmed-article:15180962 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:15180962 | pubmed:year | 2004 | lld:pubmed |
| pubmed-article:15180962 | pubmed:articleTitle | A recombinant antibody increases cardiac contractility by mimicking phospholamban phosphorylation. | lld:pubmed |
| pubmed-article:15180962 | pubmed:affiliation | Department of Medicine, University of California, San Diego, La Jolla, CA 92093-0618, USA. | lld:pubmed |
| pubmed-article:15180962 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15180962 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:15180962 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
